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A.G.E. Interrupter Wrinkle cream

A.G.E. Interrupter is rated 4.6 out of 5 by 96.
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High-concentration anti-wrinkle cream formulated to improve the visible signs of aging caused by advanced glycation end-products (A.G.E.)

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Product Details

A.G.E. Interrupter is an advanced wrinkle treatment that fights the visible signs of aging caused by advanced glycation end-products (A.G.E.), a major factor of the natural aging process. This anti-aging cream is formulated with an unprecedented 30% concentration of proxylane™, 4% blueberry extract, and 0.2% phytosphingosine (pronounced fi'to-sfing'go-sen) to improve the appearance of wrinkling and restore the loss of firmness caused by the glycation process.

  • Reduces the appearance of skin creping and thinning
  • Visibly improves the appearance of fine lines, wrinkles, and skin texture
  • Restores water and nutrients to improve the look of skin firmness
  • Comforts dry, aging skin
  • Alcohol-, and dye-free

How To Use


Once or twice daily, massage a thin, even layer onto the entire face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • visible results

    In a 12-week study, A.G.E. Interrupter showed a significant improvement in the appearance of wrinkles, firmness, and skin texture

    See Protocol

    A 12-week controlled clinical study on 41 subjects, ages 45-61. Subjects applied A.G.E. Interrupter twice daily.

  • Science & Proof

  • Science

    Intrinsic or natural aging, caused by internal factors such as hormonal shifts and changes in skin metabolism, contribute to the appearance of wrinkles, loss of firmness, and crepy skin.

    Glycation, a major factor of intrinsic aging, occurs when excess sugar molecules bind to collagen and elastin fibers and prompt the formation of advanced glycation end-products (A.G.E.). As a result, glycated collagen and elastin fibers lose the ability to function normally, and the body cannot break them down and replace them, leading to severe wrinkling of the skin.

    A.G.E. Interrupter is a uniquely-textured formulation optimized to help improve the visible signs of aging associated with glycation. This potent anti-wrinkle cream features a high-concentration combination of proxylane, blueberry extract, and phytosphingosine to improve visible signs of aging such as wrinkles, loss of firmness, and a crepy, thinning appearance.

Key Ingredients

  • 4% Blueberry extract
  • 30% Proxylane™
  • 0.2% Phytosphingosine

Naturally derived and both an antioxidant and anti-glycation ingredient helps fortify skin’s matrix and prevent the appearance of wrinkles and laxity.

Learn more about Blueberry extract

See all ingredients

aqua / water / eau, propylene glycol, dimethicone, hydroxypropyl tetrahydropyrantriol, cyclohexasiloxane, isohexadecane, glycerin, synthetic wax, dimethicone/peg-10/15 crosspolymer, aluminum starch octenylsuccinate, ci 77163 / bismuth oxychloride, phenoxyethanol, magnesium sulfate, ethylhexyl hydroxystearate, salicyloyl phytosphingosine, acrylates copolymer, methylparaben, ethylparaben, disodium edta, vaccinium myrtillus extract / vaccinium myrtillus fruit extract, parfum / fragrance, butylphenyl methylpropional, coumarin

Physician Insight

Physician image

A.G.E Interrupter is an impressive corrective cream that significantly improves the appearance of the visible signs of aging such as fine lines and wrinkles that are common as we age. It is an ideal for various skin types, and is a popular product requested by Park Avenue Medical Spa patients.

Dr. Anca Tchelebi-Moscatello - Park Avenue Medical Spa

Learn about Dr. Tchelebi-Moscatello

Complete Your Regimen


Rated 5 out of 5 by from Wish I had found product earlier I purchased the A.G.E Interrupter a few weeks ago and began to see a difference almost immediately. I am 55 and am very happy to see the fine lines around mouth and on forehead diminishing. I wish I had known about the product a few years ago, but I am glad that I overheard another customer talking about her positive results with this product and others in the line. I will definitely be continuing to use A.G.E Interrupter in my skin care regimen.
Date published: 2020-07-14
Rated 5 out of 5 by from Amazing! I have pretty oily combination skin but as I entered my 40s I knew I needed some thing stronger than a basic moisturizer. This stuff is amazing it moisturizes incredibly well and my face feels plump and smooth. I also notice the lines on my forehead have reduced. You don’t need much of this cream and I use it morning and night but I am so pleased with the results over these past six months using Age Interrupter!
Date published: 2020-07-12
Rated 5 out of 5 by from Really happy with this product! I have been using this product for several months after switching from many years of using and loving LaMer creams. This cream, along with all of the other SkinCeutical products I have been using seem to be performing most effectively. My 73 year old skin feels really nice!
Date published: 2020-07-11
Rated 5 out of 5 by from This is a heavy and amazing night cream. Made me wake up with the most amazing clear and hydrated skin of my life. Expensive but worth it. You really cannot go wrong with skinceuticals ever! I love this! Highly recommend!! Repeat user!!
Date published: 2020-06-26
Rated 5 out of 5 by from My holy grail! Even though I’m only in my mid-20s, using a medical grade eye cream now is so so important to me. This one is gentle, super moisturizing, and leaves my eyes looking wide awake in the morning. Highly highly recommend for all ages.
Date published: 2020-06-25
Rated 4 out of 5 by from The best This is, by far, my favorite moisturizer/cream! However, I’m not using it right now because of the price. If my skin could get away without having to use other products, I would splurge on this. It feels so soft and smooth on my skin, works well day and night. It is a thicker cream, but still worked well for me under make-up.
Date published: 2020-06-25
Rated 5 out of 5 by from I originally was exposed to this product as a sample but after a few uses I knew I had to have this product! It fits really well with my other products but especially compliments my skinceuticals vit c serum
Date published: 2020-06-22
Rated 4 out of 5 by from It’s super super thick but doesn’t break me out. I would say that compared to my summer Fridays it’s not quite as hydrating. The thickness is such that it doesn’t absorb as well into my skin. Plus it’s pretty expensive.
Date published: 2020-06-21
Rated 5 out of 5 by from Amazing skincare I absolutely love Skin Ceuticals. I have been using their products since I was 28 and am now 50. I get compliments on my skin all the time. For reference I use the regimen with age interrupter; CE freulic and Hyaluronic acid. I have tried pretty much every quality brand and continue to try new products but SC is the best!
Date published: 2020-06-20
Rated 5 out of 5 by from Love it About 6 month ago I had something going on around my eyes. The skin around eyes became very dry and itchy and with little painful cracks. I called to cancel my facial massage due to this condition, however my beautician ask me to try this AGE interapter. She gave me little sample couple weeks before it. I was afraid to try it because any lotion that I tried before it would burn my skin and make it even worse. However, this one helped. Couple days later I got my skin back, and since then I am using AGE INTERAPTER every day before bed. I personally think my wrinkles got softer look, and skin feels like new born skin. Now I am waiting for my second jar to come.
Date published: 2020-06-19
Rated 4 out of 5 by from Love this product! It’s creamy and it prevents wrinkles! I have seen a difference in my skin!
Date published: 2020-06-02
Rated 5 out of 5 by from Outstanding product! I have used A.G.E. Interrupter for many years and am very pleased with the results. It has helped my skin to retain moisture and reduced the deepening of wrinkles. A.G.E. Interrupter is a staple for me!
Date published: 2020-06-01
Rated 5 out of 5 by from It works! I have been using for about 6 weeks, and there is a noticeable difference in the appearance of my facial skin. Lines and wrinkles have visibly decreased. I recommend. It goes on so smooth and easy, it is a delightful product to use.
Date published: 2020-05-31
Rated 5 out of 5 by from Skinceuticals Favorite This is my favorite product in my Skinceuticals nighttime regimen. My skin looks and feels flawless after applying this and looks just as good the next morning. Product glides onto skin easily and is easily absorbed. It helps moisture my skin as well as working on the aging process of wrinkles.
Date published: 2020-05-29
Rated 5 out of 5 by from A misconception about this cream is that people use it solely as a moisturizer. This product is a CORRECTIVE product. It should be paired with a moisturizer because it does not have any moisturizing properties. It is amazing for deeper wrinkles and damaged skin!
Date published: 2020-04-27
Rated 5 out of 5 by from I have tried almost every moisturizer under the sun for my dry skin. This one is my favorite.
Date published: 2020-04-20
Rated 5 out of 5 by from Great product for men’s combination skin Great product for men’s combination skin I’ve been using this product along with several other of their products and certain doctor prescription items all at the recommendation of my dermatologist the AGE interrupter cream is great and reasonably priced when compared to many of the other department store creams I’ve used in the past which can go for up to over $1000 use it as part of my nighttime regime I’ve been enjoying it for several years now
Date published: 2020-04-16
Rated 2 out of 5 by from Overpriced I do not understand why the price is so expensive. I have not noticed improvement in my skin and I'm on my second jar. I can no longer justify the price.
Date published: 2020-03-22
Rated 3 out of 5 by from Parabens? I love SkinCeuticals products. Recently i have been trying to learn more about what is actually in them. i was disappointed to find out that two of the products that I love contain parabens, is this associated with it being an anti-aging product? I am not sure why its highlighted in so many products that they don't contain parabens but then the Age interupter cream has parabens? Also wondering about propylene glycol as another added ingredient as I've heard its been shown to weaken protein and cellular structure of the skin.
Date published: 2020-02-27
Rated 1 out of 5 by from changed formula? This A.G.E. cream is different than the last time I got it. It is white and has a whipped, greasy texture. I'm 49. I could see and feel the effects of the last cream in one day. THIS cream does not absorb into my skin. I've been using it for two weeks, and it does NOTHING for my skin. I hope the formula hasn't changed, and this some kind of fluke with the distribution. I contacted the company and didn't receive a response. By writing a review maybe it will respond to my complaint.
Date published: 2020-02-25
Rated 4 out of 5 by from AGE it feels wonderful on my face. I’ve received several samples of this and I love it. I’m sure the Ingredients would show results. I haven’t purchased it because personally it is too expensive. I just can’t bring myself to pay that much for a face cream. I save for procedures that I like to get often instead. Can’t give five stars because of the price.
Date published: 2020-01-20
Rated 5 out of 5 by from Love this product!!!! I have purchased thousands of dollars for skin care over the past 10 years. THIS! I love this cream. My face feels so refreshed after using and I absolutely love it. I believe it is worth every penny!
Date published: 2020-01-19
Rated 2 out of 5 by from Disappointed Iv used it for a week No results a way over priced product that leave my skin needed additional moisturizer.. will give it Another week if no results sending this product back
Date published: 2019-12-29
Rated 5 out of 5 by from Let me start by saying Mine says Skin Ceuticals A.G.E. Rye Complex.. it’s Absolutely Wonderful and it really works , I love it , I have been using it for two years
Date published: 2019-11-26
Rated 1 out of 5 by from Fresh smell It did nothing more than over the counter products I have tried. I have used other Skin products from this company that did a good job but not this one. When you apply makeup over it the makeup gets cakey and doesn't look good.
Date published: 2019-10-22
Rated 5 out of 5 by from My skin loves this stuff!!! I am so glad this was reccomend to me after a hydrafacial. My skin went from oily to dry and flaky the past couple of years. The years of sun exposure certainly have made numerous line appearances especially on my forehead and eye areas. The first time I used it my skin soaked this in. It's a thick cream and perhaps I went a bit crazy with it at first and if you oversupply you will have some residue left. ( the only thing I dont like). After a few weeks of continuous use I started to see a difference. My skin is hydrated and firmer and it is no longer red and flaky. I look refreshed and I will never be without this product. The only thing I would suggest to Skinceuticals is to maybe add sunscreen. I use the Ultimate UV Defense SPF 30 which I love but I wouldn't mind having it all in one jar.
Date published: 2019-09-09
Rated 5 out of 5 by from Makes my face feel light. Love it. I see the wrinkles fading. I love the line. I always have a face cream on
Date published: 2019-07-19
Rated 5 out of 5 by from This product is thick in consistency, but spreads nicely and wears well under makeup. It is very moisturizing and makes my skin feel smooth. A little goes a long way. I have seen a reduction in fine lines and sagging. The directions say this product is a treatment and to put moisturizer on top of this product. I find that my skin feels moisturized without having to put another layer on. Great for dry skin.
Date published: 2019-06-19
Rated 3 out of 5 by from Why Fragrance? This is a decent smoothing product. But why on earth does Skinceuticles put parfum/fragrance in it. I may be an old lady but I sure don’t want to SMELL like one!
Date published: 2019-06-16
Rated 5 out of 5 by from Best moisturizer I’ve ever used This is by far the best moisturizer I’ve ever used. It’s lite wait and none greasy. Although it’s a pricey, I can actually see results in the disappearance of my fine lines. I would absolutely recommend this product.
Date published: 2019-06-09
  • y_2020, m_10, d_25, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_2, bvpage2n
  • co_hasreviews, tv_0, tr_96
  • loc_en_US, sid_635494345001, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_skinceuticals-us
  • bvseo_sdk, dw_cartridge, 17.1.0, p_sdk_3.2.0
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