Product Details
Discoloration Defense is a layerable, daily-use dark spot corrector clinically proven to reduce the appearance of key types of skin discoloration in all skin tones, including hard-to-treat forms such as stubborn brown patches and post-acne marks. Formulated with 3% tranexamic acid, 1% kojic acid, 5% niacinamide, and 5% HEPES, this latest-generation formula improves the appearance of skin discoloration, brightens skin, and evens skin tone in as early as 2 weeks.
- Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
- 60% average improvement in the appearance of stubborn brown patches1
- 34% average reduction in post-blemish marks in deeper skin tones2
- Paraben-, fragrance-, silicone-, gluten-, and hydroquinone-free
- Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations
1Protocol: Average results shown. A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild to moderate facial skin discoloration, including stubborn dark spots, post-acne marks, and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
2Protocol: A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
How To Use
- Twice daily, apply 3-5 drops of this skin discoloration serum to the face.
- If using in the morning, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad spectrum SPF 50+ sunscreen.
- Limit sun exposure while using this product.
- Do not use on irritated or broken skin. If irritation occurs, discontinue use.
-
Visible Results
- 60% average improvement in the appearance of stubborn brown patches
- 59% average improvement in the appearance of skin discoloration
- 81% average improvement in the appearance of post-acne marks
- 59% average improvement in the appearance of even skin tone
- 34% reduction in post-blemish marks at 12 weeks
-
Science & Proof
In a 12-week clinical study, Discoloration Defense significantly improved the appearance of key skin discoloration markers:
See Protocol
Protocol: Average results shown. A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild to moderate facial skin discoloration, including stubborn dark spots, post-acne marks, and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
In a new 12-week study on deeper skin tones (Fitzpatrick V-VI), twice-daily application of Discoloration Defense demonstrated a statistically-significant reduction in the appearance of discoloration, post-inflammatory discoloration, and even skin tone.
See Protocol
Protocol: A 12-week, single-center, clinical study was conducted on 51 female subjects, Fitzpatrick V-VI, with visible signs of skin discoloration/hyperpigmentation, including post-inflammatory hyperpigmentation and melasma. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.
Everyday elementsāincluding UV exposure, prescription drugs, and some professional treatmentsācan trigger production of melanin in the skinās lowest epidermal layers. This excess melanin rises to the surface of the skin, causing visible skin discoloration. Discoloration can manifest in a range of ways, including post-acne marks and stubborn brown patches on the cheekbones, forehead, and upper lip.
Discoloration Defense is the latest-generation dark spot corrector, using a combination of potent and proven anti-discoloration ingredientsāincluding new tranexamic acidāto address key types of skin discoloration.
Key Ingredients
- 3% Tranexamic Acid
- 1% Kojic Acid
- 5% Niacinamide
- 5% HEPES
This synthetically-derived ingredient minimizes the reoccurrence of skin discoloration and stubborn brown patches with continued use.
Learn more about Tranexamic AcidSee all ingredients
Aqua / Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta
Physician Insight

I recommend Discoloration Defense between chemical peels- this formula targets stubborn types of discoloration but is gentle on my patientsā skin, making it ideal for an at-home regimen between treatments.
Dr. Sarah Sawyer
Learn about Dr. Sarah SawyerComplete Your Regimen
-
preventPhloretin CFĀ® with Ferulic Acid
$166.00
A patented daytime vitamin c antioxidant face serum that delivers advanced environmental protection and diminishes the appearance of fine lines and discoloration. U.S. Patent No. 9,248,082.skin types- Normal
- Oily
- Combination
-
correctMetacell Renewal B3
$112.00
A comprehensive daily emulsion formulated to improve the appearance of early signs of agingskin types- Dry
- Normal
- Oily
- Combination
- Sensitive
-
protectPhysical Fusion UV Defense SPF 50
$34.00 - $66.00
A tinted sunscreen fluid with 100% mineral filters provides broad spectrum UVA/UVB protection, while promoting natural radiance and a more even skin toneskin types- Dry
- Normal
- Combination
- Sensitive
-
protectPhysical Eye UV Defense SPF 50
$30.00
A 100% mineral, tone-enhancing tinted sunscreen formulated for the delicate eye area.skin types- Dry
- Normal
- Oily
- Combination
- Sensitive