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Discoloration Defense Skin discoloration serum

Discoloration Defense is rated 4.2 out of 5 by 47.
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Daily dark spot corrector targets visible skin discoloration for brighter, more even-looking skin

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Product Details

Discoloration Defense is a layerable, daily-use dark spot corrector clinically proven to reduce the appearance of key types of skin discoloration, including hard-to-treat forms such as stubborn brown patches and post-acne marks. Formulated with 3% tranexamic acid, 1% kojic acid, 5% niacinamide, and 5% HEPES, this latest-generation formula improves the appearance of skin discoloration, brightens skin, and evens skin tone in as early as 2 weeks.

  • Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
  • 60% average improvement in the appearance of stubborn brown patches
  • Paraben-, fragrance-, silicone-, gluten-, and hydroquinone-free
  • Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations

How To Use

  • Twice daily, apply 3-5 drops of this skin discoloration serum to the face.
  • If using in the morning, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad spectrum SPF 50+ sunscreen.
  • Limit sun exposure while using this product.
  • Do not use on irritated or broken skin. If irritation occurs, discontinue use.
  • Visible Results

  • before

    In a 12-week clinical study, Discoloration Defense significantly improved the appearance of key skin discoloration markers:

    • 60% average improvement in the appearance of stubborn brown patches
    • 59% average improvement in the appearance of skin discoloration
    • 81% average improvement in the appearance of post-acne marks
    • 59% average improvement in the appearance of even skin tone

    See Protocol

    Protocol: Average results shown. A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild to moderate facial skin discoloration, including stubborn dark spots, post-acne marks, and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen. Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.

  • Science & Proof

  • Science

    Everyday elements—including UV exposure, prescription drugs, and some professional treatments—can trigger production of melanin in the skin’s lowest epidermal layers. This excess melanin rises to the surface of the skin, causing visible skin discoloration. Discoloration can manifest in a range of ways, including post-acne marks and stubborn brown patches on the cheekbones, forehead, and upper lip.

    Discoloration Defense is the latest-generation dark spot corrector, using a combination of potent and proven anti-discoloration ingredients—including new tranexamic acid—to address key types of skin discoloration.

Key Ingredients

  • 3% Tranexamic Acid
  • 1% Kojic Acid
  • 5% Niacinamide
  • 5% HEPES

This synthetically-derived ingredient minimizes the reoccurrence of skin discoloration and stubborn brown patches with continued use.

Learn more about Tranexamic Acid

See all ingredients

Aqua / Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta

Physician Insight

Physician image

I recommend Discoloration Defense between chemical peels- this formula targets stubborn types of discoloration but is gentle on my patients’ skin, making it ideal for an at-home regimen between treatments.

Dr. Sarah Sawyer

Learn about Dr. Sarah Sawyer

Complete Your Regimen


Rated 5 out of 5 by from Works!! I been used this product for a month ago, I have this very dark/texture spots , in my cheeks , nose , since a been used this product it got lighter, the process is slow ( I think is beacuse my spots are very dark) but it works . I used vitamin C, then Discoloration defense and sunblock ( everything from skinceuticals) I recommend it!
Date published: 2019-04-20
Rated 5 out of 5 by from It really works I have noticed clearer brighter skin in just a few weeks. I do use it with Metacell Renewal which is also supposed to help with my hyperpigmentation concerns. All you need is three drops.
Date published: 2019-04-19
Rated 2 out of 5 by from Not easy to see results I used one whole bottle and I did not see any results.
Date published: 2019-04-19
Rated 5 out of 5 by from Just the sample When I tell u Im not one to spend alot on face care, I will gladly spend my money with Skinceuticals! I am so grateful for this brand, Everything that I use and try I am so impressed! This product, just the sample, has lightened my dark spots in just 3 weeks, I can cry! I thank you for creating a face wash (lha cleansing gel) and this discoloration defense, together my face is flawless!
Date published: 2019-04-17
Rated 4 out of 5 by from This product makes my face brighter. I like to use it before moisturizer. Its set at an average price for what you get. Which is and average size bottle. The product goes a far ways with a little bit of use.
Date published: 2019-03-28
Rated 1 out of 5 by from No results Did not change a thing. Spots and hyperpigmentation has no change at all.
Date published: 2019-03-25
Rated 5 out of 5 by from Amazing product !!’ Received this product as a sample and used only for two weeks it works really well I can see the visible difference
Date published: 2019-03-20
Rated 5 out of 5 by from Great Product This product has done wonders for my skin. It's literally glowing. I use this in combination with the Phlorentin CF. The two together are amazing.
Date published: 2019-03-16
Rated 5 out of 5 by from I tried a sample of this not to long ago from an offer they were doing on their website! I would absolutely love to have a full size bottle of this awesome innovative product! The price is a little steep but T totally worth it! Every review from every product they offer has amazing reviews from people that have seen automatic results! The sample I received was though of good size so maybe before purchasing a full size product you may could email them asking for a sample sized of their brand to try? Just a suggestion ! I really do love this brand! Would definitely love to try more products from their skincare line!!!! SkinCeuticals C E Ferulic Combination Antioxidant Treatment
Date published: 2019-02-26
Rated 5 out of 5 by from Ive heard amazing things about this product. I suffer from discoloration around my mouth and I tried it from a friend and looooved it!
Date published: 2019-02-26
Rated 5 out of 5 by from This feels almost oily going on but quickly settles into skin. I feel like it hydrated a little. After a few days of use my dark spots from acne seemed to lighten for a more even complexion. I really do like this serum and will for sure repurchase.
Date published: 2019-02-26
Rated 5 out of 5 by from Fabulous product. The entire line is healthy, medical grade and very hydrating. It's a light serum that really does do what it says. You don't be disappointed. I will be repurchasing this.
Date published: 2019-02-26
Rated 4 out of 5 by from I liked it so much that I used it in the evening before going to bed and my skin helped to improve in the last period thanks to its ingredients Helps the skin to get rid of dead skin cells and works to lighten with continuous use I want to try other products of this brand and be suitable for oily skin and acne
Date published: 2019-02-26
Rated 5 out of 5 by from The first time I tried this was a sample I received from pinch me it worked great for the discoloration around my mouth and spots on my faces they are slowly going away it's a very good product for anyone with the same problems I have I say you might want to try the sample first before you buy it because everyone's body is not alike.
Date published: 2019-02-26
Rated 5 out of 5 by from Omg the way this is let me tell you perfwct serum for persons with sensitive skin and oily skin as well. I jse mine almost everyday. Which is in my daily skin care routine
Date published: 2019-02-26
Rated 5 out of 5 by from I just starting using this product, Im alternating between it and SkinCeuticals C and E Ferulic acid everyday. I may try to use only this one to see if I can get results sooner. I have several dark spots on my cheeks that Im looking to lighten. I do like the weight and feel of it. My esthetician calls the SkinCeuticals C and E Ferulic acid a game changer so Im hoping this product will be as well.
Date published: 2019-02-26
Rated 5 out of 5 by from Great serum. My skin does not react to it which I like! I have a lot of scarring as well as sun damage which this helps with!
Date published: 2019-02-26
Rated 5 out of 5 by from Amazing product! I have medium tan skin and suffer from hyperpigmentation post acne. Sometimes the marks can last for months after a break out! I recieved a sample of this from my skincare provider and it worked wonders in 2 weeks, I couldnt believe it. My dark spots have lessened, some have even dissappeared completely. I have purchased a full size bottle and have made it a part of my daily routine and have seen significant improvements! Highly recommend.
Date published: 2019-02-19
Rated 1 out of 5 by from Waste of money and time but not irritating at leas Both my husband and I have used this for months, him for 2 acne scars and me for a couple of age spots. Neither of us has seen any difference at all and bottle is almost done but at least it wasn’t irritating. Waste of money big time and waste of time as we could have been using something else all these months. If you can get a sample first try that because this lesson cost us plenty!
Date published: 2019-02-14
Rated 4 out of 5 by from I do see results I have sun spots around my eyes and because they're around my eyes IPL and BBL can't address them. I have been using Discoloration Defense for about a month and do notice a slight improvement in the darkness and size of the spots. I hope with continued use the spots will continue to fade. The only reason I didn't give 5 stars is that it's a slow process.
Date published: 2019-01-31
Rated 1 out of 5 by from Disappointed I just finished the bottle. Followed the directions precisely. This product did absolutely nothing to lighten a dark spot on my face. I have used other products from your company faithfully for years and would not be without them——C E FERULIC, B 5 SERUM, and 30 SUNSCREEN. This product simply did not work.
Date published: 2019-01-05
Rated 5 out of 5 by from Goodbye Dark Spots This product is the real deal! I bruise easily, and the only product that worked in the past was prescribed by a doctor. This is by far the best over the counter product that I have ever used. I saw my pimple spots fading after using Discoloration Defense in one week
Date published: 2018-12-27
Rated 1 out of 5 by from normal to oily skin I purchased discoloration 2 yrs ago -I finished one bottle and one to my next one - I see no difference with my 1 dark spot on my cheek.
Date published: 2018-12-24
Rated 1 out of 5 by from Saw absolutely no difference I bought and used the entire bottle and saw no difference in my skin. I am dark skinned (African/Jamaican/Irish) with what seems like melasma and this product made no difference.
Date published: 2018-12-07
Rated 5 out of 5 by from Truly Works It took about 3 weeks for me to see improvement, but the hyperpigmentation and stubborn brown patches are lightening and decreasing in size.
Date published: 2018-11-26
Rated 4 out of 5 by from Definitely effective I bought this product about two months ago because at my age now (65) if I get a blemish, it gets really red and is now taking forever to fade. This product has definitely accelerated the healing and fading of these spots. I'm not sure about the brown spots, but will be monitoring them as I continue using the product. It does have a bit of a sticky texture, but it works so I will work with it.
Date published: 2018-11-09
Rated 5 out of 5 by from Amazing New Product I purchased a bottle after having aerolase treatments at Manhattan Aesthetics and was totally shocked by how great this product is. Post laser I traveled to South America and I swear it has prevented my sun damage from coming back.
Date published: 2018-11-03
Rated 3 out of 5 by from My second bottles I am on my second bottle. It works very slow. But I will give another chance on my second bottles.
Date published: 2018-10-08
Rated 4 out of 5 by from AN AWESOME PRODUCT This product is one of its kind, l'm so glad l bought the vitamin c, it worked so well for me,l will buy more whenever its on sale.
Date published: 2018-09-19
Rated 5 out of 5 by from I love ❤️ it Wow Discoloration Defense is the best for me. I had a lot of Sun spots since I’ve been using this my face is a lot lighter. Thank you Skin Ceuticals for this product really works .
Date published: 2018-09-11
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