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Metacell Renewal B3 Lightweight lotion for skin with niacinamide (vitamin B3)

Metacell Renewal B3 is rated 4.7 out of 5 by 26.
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A comprehensive daily emulsion formulated to improve the appearance of early signs of aging

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Product Details

Metacell Renewal B3 utilizes a patent-pending aqueous emulsion to deliver a high concentration of 5% niacinamide (vitamin B3) combined with a firming tripeptide concentrate, and 15% pure glycerin to address early signs of photoaging. While signs of photoaging appear at different intensities according to skin biology, lifestyle, geography, sun protection behavior, and skincare regimen, they have a multiplicative effect, creating a prematurely-aged appearance. This comprehensive daily emulsion visibly improves these early signs of photoaging by increasing cell turnover to resurface skin, help reclarify and even skin tone, and improve the appearance of wrinkles and surface elasticity.

  • Promotes skin renewal by increasing cell turnover
  • Strengthens skin’s moisture barrier
  • Reduces the appearance of discoloration and blotchiness
  • Lightweight emulsion delivers intense hydration without a heavy or tacky feel
  • Helps improve the appearance of skin’s firmness

How To Use


Twice daily, massage 1-2 pumps into a thin, even layer onto the entire face, neck, and chest.

  • Visible Results

  • visible results

    In a 12-week clinical study, Metacell Renewal B3 showed significant improvement in signs of photoaging:

    • 15% improvement in the appearance of radiance and luminosity
    • 20.9% improvement in the appearance of fine lines
    • 10.9% improvement in the appearance of firmness

    See Protocol

    A dermatologist-controlled 12-week clinical on 56 female subjects, ages 40-55. Subjects applied Metacell Renewal B3 twice daily. Subjects also used SkinCeuticals Gentle Cleanser and Physical UV Defense SPF 30 as needed.

  • Science & Proof

  • Science

    While signs of photoaging appear at different intensities according to skin biology, lifestyle, geography, sun protection behavior, and skincare regimen, they have a multiplicative effect, resulting in a prematurely-aged appearance.

    Niacinamide has been extensively studied for over 30 years within the dermatological and scientific community for its multi-factorial benefits on photoaging. Traditional delivery methods to optimize niacinamide on skin can disrupt the skin’s barrier and counteract the moisturizing and protective benefits. SkinCeuticals research labs have formulated a new delivery system to resolve this limitation. The non-disruptive delivery system of the formula architecture optimizes niacinamide delivery, while reinforcing the skin’s barrier. It is free of ingredients that traditionally occlude skin’s barrier, in order to allow niacinamide to be effective on skin.

Key Ingredients

  • 5% niacinamide (vitamin B3)
  • 2.5% firming tri-peptide concentrate
  • 15% pure glycerin

Helps reduce the appearance of skin discoloration and strengthens skin’s moisture barrier

Learn more about niacinamide (vitamin B3)

See all ingredients

aqua / water / eau, glycerin, dimethicone, niacinamide, propanediol, dimethicone/peg-10/15 crosspolymer, methylsilanol/silicate crosspolymer, sodium chloride, polymethylsilsesquioxane, phenoxyethanol, microcrystalline cellulose, ci 77163 / bismuth oxychloride, chlorphenesin, caprylyl glycol, sodium citrate, ethylhexyl hydroxystearate, peg-10 dimethicone, disodium edta, cellulose gum, laminaria digitata extract, adenosine, citrus aurantium amara flower oil / bitter orange flower oil, melaleuca viridiflora leaf oil, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, linalool, cymbopogon flexuosus oil, citral, limonene, pelargonium graveolens flower oil

Physician Insight

Physician image

Metacell Renewal B3 is a light and hydrating moisturizer that improves skins laxity and helps prolong the results of a Chemical Peel and Laser treatment!

Dr. Kim Nichols – NicholsMD of Greenwich

Learn about Dr. Kim Nichols

Complete Your Regimen


Rated 5 out of 5 by from Amazing Product!!! Metacell B3 transformed my oily, clogged, acne prone red and blotchy sensitive skin into smooth, clear and even toned. I can't say enough great things about this product. This is my regimen: Clarifying Cleanser, LHA toner, pat face with water to dampen my skin then mix CE Ferulic with Hydrating B5 gel and then apply Metacell B3. I do this morning and night, using Physical Fusion as my sunscreen in the AM. This regimen has transformed my skin and I am so grateful. I am in love with Skinceuticals products! After using so many products for years that didn't work, I will always be loyal to is worth every penny! Please never change this formulation!!!! I hope this post will help someone else who has similar skin as mine and has tried everything and is not sure if this product is right for them.
Date published: 2015-12-20
Rated 5 out of 5 by from @skinceuticals Metacell Renewal B3 aka IPL in a bottle. Packed with nacinamide for lightening dark spots, tripeptides to help tighten sagging skin and glycerin to help pulp and retain moisture. Plus the emulsion turned serum is perfectly packaged in pump pack that prevents oxidation and product waste. #skinforthewin #selfcareeveryday #skincarecommunity #selfcare #antiaging #beautyproducts #beautyblogger #aginggracefully #houstonblogger #serums #vitamina #oils #masks #organic #antioxidant #beautyroutine #greenbeauty #naturalbeauty #beautyceuticals
Date published: 2019-02-26
Rated 5 out of 5 by from Excellent lightweight moisturizer I've used this product as an adjunct to my skin care routine to add lightweight corrective moisture and I couldn't be happier. In the morning, I layer this on top of my antioxidant, under my sunscreen and for evening use, I use it with my retinol product. I've also used it safely post-peel procedure with no irritation.nnMy skin is hydrated, nicely toned and my sun spots have lightened. I've received many complements since I started using this product, many people can't believe I'm almost 50!
Date published: 2015-11-20
Rated 5 out of 5 by from Amazing!!! I bright this a month ago and I am so happy I did! I use it Morning under make up and at night before bed.
Date published: 2020-01-22
Rated 5 out of 5 by from Lightweight moisturizer for hot humid weather I've been using Skinceuticals products for a year and I am glad that I finally find a lightweight moisturizer that I can use in Florida. I use CEF+B5+AGE eye+Metacell in the morning and Retexturing+Photo+AGE eye+Metacell at night. I also apply blemish defense only on the area with occasional acnes and it reduces the breakout. Skinceuticals really works!
Date published: 2017-03-24
Rated 5 out of 5 by from Loved it This is the best moisturizer I have ever used. I have oily skin, discoloration, and I had breakouts very often. After I started using this product, I had no more breakouts, and my skin looks so good. I believe it helped with the discoloration as well, the skin looks brighter and the dark spots are fading, althought I am using other Skinceuticals products for this problem as well. The product does not feel heavy on the face, and make up goes well over it. I just wish the amount of product would be greater than 50ml, as it ends too fast.
Date published: 2019-06-10
Rated 5 out of 5 by from Absolute favorite! I’ve been using SC poroducts for many years now. Occasionally I’ll switch to other lines but do have my favorites in this line. This product is extremely light and leaves your skin feeling and looking silky smooth. I use it after my corrective serums and before I moisturize. I have very sensitive skin and have never have any negative reactions from it. You won’t be disappointed.
Date published: 2017-10-16
Rated 5 out of 5 by from I have not had a single breakout since using this product, which I never thought Id ever experience! The clarity and wrinkles have improved as well. Love this stuff, hate the price tag though.
Date published: 2019-02-26
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