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Retinol 0.5 Retinol night cream for face

Retinol 0.5 is rated 4.5 out of 5 by 69.
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A concentrated night cream with pure retinol improves the appearance of visible signs of aging and pores while minimizing breakouts

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Product Details

Retinol 0.5 contains 0.5% pure retinol and is enhanced with the latest stabilization and delivery technologies to ensure a steady, even release. Designed to help diminish the appearance of fine lines, wrinkles, and skin discoloration, this retinol night cream can refine the appearance of pores, while reducing the appearance of blemishes associated with problematic skin.

  • Promotes cell turnover
  • Improves the appearance of fine lines, wrinkles, discoloration, pores, and blemishes
  • Formulated to minimize irritation commonly associated with the use of retinol night creams
  • Specialized packaging preserves retinol potency
  • Non-comedogenic, paraben-, fragrance-, and gluten-free
  • Ideal for skin preconditioned with Retinol 0.3

How To Use

In the evening, apply 4‐5 drops to clean dry skin, avoiding the eye area. Allow product to absorb before applying other skincare products. Limit initial use to once or twice a week, gradually increasing frequency to every other night, then every night as tolerated. It is important to establish consistent skin tolerance before advancing to a higher concentration.

Retinol may increase photosensitivity. Always use a high-protection, broad spectrum sunscreen when using this product.

As a precaution, retinol cream products should not be used by pregnant women or women who intend to become pregnant in the near future. Though there are no reports of topical retinol having any negative effect on fetal development, always consult a physician.

  • Science & Proof

  • Science

    Topical retinols have extensively been used by dermatologists to help combat and reverse the visual effects of aging, such as wrinkles, laxity, and discoloration. Retinols because they accelerate cell turnover, can also improve blemishes and the appearance of pores. The retinol molecule is highly-sensitive and vulnerable to breakdown if not properly protected. Retinol 0.5 employs an optimized delivery system and protective packaging to ensure stability and efficacy of pure retinol. This retinol night cream works with skin’s natural lipid structure to promote optimal absorption.

Key Ingredients

  • 0.5% Retinol
  • Soothing complex

A derivative of vitamin A, this powerful molecule promotes cellular turnover to help improve the appearance of fine lines, wrinkles, and discoloration. It also helps minimize blemishes while reducing the appearance of pores.

Learn more about Retinol

See all ingredients

aqua / water / eau, propanediol, dimethicone, cetearyl ethylhexanoate, alcohol denat., dipropylene glycol, ammonium polyacryloyldimethyl taurate, allyl methacrylates crosspolymer, acrylamide/sodium acryloyldimethyltaurate copolymer, hydrogenated lecithin, isohexadecane, retinol, phenoxyethanol, caprylyl glycol, polysorbate 20, isopropyl myristate, sodium citrate, boswellia serrata gum, polysorbate 80, dimethiconol, trisodium ethylenediamine disuccinate, bisabolol, bht, sorbitan oleate, citric acid, propyl gallate

Physician Insight

Physician image

I always start my patients on Retinol 0.5 at night. It is a great way to achieve a visible change in skin tone, and an essential building block for a solid skin care program.

Dr. Richard Zeff – Zeff & Wilson Plastic Surgery

Learn about Dr. Richard Zeff

Complete Your Regimen


Rated 5 out of 5 by from Perfect Strength! I slowly increased this product and now use it nightly. Love the way it makes my skin feel.
Date published: 2019-04-26
Rated 5 out of 5 by from She Glows - I woke up like this!!! I got a sample of the 0.5 strength from my local Bluemercury (enough for 3 days use) and I kid you not after I was done, my skin looked so radiant!! I looked in the mirror like "I woke up like this"!;) I've always had pretty good skin (clear and even) but this definitely gave me the wow glow factor and after only a few days of use!! I'm a believer. I am heading to purchase this product after work!! I am also mulling over the CE Ferulic! Got any samples of that you can send me???? :-)
Date published: 2019-04-24
Rated 5 out of 5 by from Great product! I've been using this for over a year and a half, and I have noticed an improvement in my skin tone.
Date published: 2019-04-22
Rated 5 out of 5 by from Clear It really works. Whenever you need to get rid of the dead skin but this product.
Date published: 2019-04-21
Rated 5 out of 5 by from High quality product! I’m a week in and the results are amazing. It’s cleared my hormonal acne and my overall complexion is improving significantly. My fine lines and wrinkles are diminishing. I use this in conjunction with CE Freuilic and their SPF 50.
Date published: 2019-04-21
Rated 5 out of 5 by from It's pretty awesome I'm in my late thirties with stubborn acne and this has helped tremendously. I'm into my second month now and notice my skin is smoother.
Date published: 2019-04-20
Rated 5 out of 5 by from Perfect dose. I was recommended this by my aesthetician to help with some hormonal skin congestion. Used every other night. Within about 1-2 weeks my skin began to clear right up. No dryness or flaking with this dose. I’ve now been using about a year and a half I can go makeup free. My skin looks more than a decade younger than it is! Highly recommend.
Date published: 2019-04-20
Rated 5 out of 5 by from Great Retinol! This retinol is so amazing! Retinol is so important for my skincare routine and this one does not make you peel, it’s great for every other day or to get your skin used to retinol.
Date published: 2019-04-20
Rated 5 out of 5 by from Reduced fine lines I started using retinol 6 months ago starting with 0.3 and now using 0.5. The fine lines under my eyes have almost completely gone away. My skin is delicate and renewed. I’m so happy with the results. Ant wait to see what a year use brings me.
Date published: 2019-04-19
Rated 5 out of 5 by from This retinol is great! I highly recommend it. I got a prescription retinol from a doctor which costs $300 a pop. So I looked for alternatives with high concentration. Most over the counter creams have ineffective retinol. I must say that this retinol is great! It's highly concentrated and it doesn't irritate my sensitive skin. I've tried higher concentration and it was too much for me. This one (0.5) makes my face much smoother and brighter without irritation. Also, wrinkles are less noticeable. I'm over 40. It also lasts a long time and doesn't cost nearly as much as the prescription does. I highly recommend it.
Date published: 2019-04-19
Rated 5 out of 5 by from Works well! Works well but start with a VERY small amount and blend it with moisturizer. I use it once or twice a week.
Date published: 2019-04-19
Rated 5 out of 5 by from Must have I’ve been using this product for the last 6 months. It’s a must have in my daily regimen. My skin is brighter and fine lines have lessened.
Date published: 2019-04-19
Rated 5 out of 5 by from Can't beat this! I have been using SkinCeutical's Retinol 0.5% cream for years now and have consistently loved the results! I find that the price is very reasonable for how long this product lasts and I am able to get all of the product out of the tube, which is a huge plus. I started using this twice a week, then every other night, and now use it nightly with great results! I have purchased this for friends as well, and they all have loved it! Thank you, SkinCeuticals!
Date published: 2019-04-19
Rated 5 out of 5 by from Nice results I have been using this for a long time. I have never experienced any irritation. I love how it glides on.
Date published: 2019-04-19
Rated 5 out of 5 by from Great Product!!! I bought this product after I got a sample size (which lasted for a few months)! I love this skin care line & the products I have bought so far. And after seeing the great results after just a few uses, & even better results a month after I knew I had to buy the full size. This has helped my face so much, (not that I broke out that much) but when it was close to that time of the month I would break out around my hair line & face. I think at first I used it every night, & then I would do it every other night or depending on how my face was looking. And this helped so much, & I can see that my pores esp. on my nose are smaller & its just amazing how I don't break out that much even when it comes closer to that time of the month! Whenever I notice that I'm getting a zit I put some of this stuff on it. And it has helped me NOT pick at my face/zits because I know if I leave it alone after putting this on it, it will go away. Its great to see that I'm getting my money's worth, & that the product actually works, so I'm very happy! I would def. recommend this product to a friend.
Date published: 2019-04-02
Rated 5 out of 5 by from I LOVE this stuff. You have to be very careful and use sparingly and seldomly when starting out or your face will look like a lizard. But when done right, it really resurfaces the skin so it's very smooth and even. I can't wait to see what the long term effects are. I use a pea sized amount. It has little to no smell. The packaging is simple and performs wonderfully for the product. When applied it feels very smooth almost like a face primer (it's not- only use at night!). I am impressed. It's worth every penny.
Date published: 2019-02-26
Rated 5 out of 5 by from Love this. I have break out prone skin and this help tremendously. I only use it about once every other day.
Date published: 2019-02-26
Rated 5 out of 5 by from 100% worth the price. I wake up and my skin tone is even and my pores and any acne spots are refined.
Date published: 2019-02-26
Rated 5 out of 5 by from This is the best Retinol product I've ever used. I plan to continue using and I would like to work my way up to the 1.0 strength. If you've already used Retinol creams, you will probably be able to use this product daily or every other day. I previously used Neutrogena and Roc products and I had minimal issues with irritation when I switched to this cream. If you are brand new to retinol, take you time with it because you will have some skin irritation. Remember to use spf during the day
Date published: 2019-02-26
Rated 5 out of 5 by from Beauty secret busted! Seriously, HOW did I just find out about retinol!?!? This stuff is liquid gold. My skin was able to handle this every night from the get go (you are supposed to taper yourself, starting with once or twice a week and building up to daily use then increasing the strength). Ill never look back, my skin has drastically changed in front of my eyes. Thank you skinceuticals!!!
Date published: 2019-02-26
Rated 5 out of 5 by from LOVE LOVE LOVE. This retinol is fantastic and I can definitely see a difference in the brightness, firmness and evenness of my skin! Worth it!
Date published: 2019-02-26
Rated 5 out of 5 by from The best! As with anyone it took my skin some time to get use to. I use this along with Triple Lipid Restore 2:4:2 to help regenerate my skin, help with fine lines and texture. My skin has been more even with a Radiant appearance!
Date published: 2019-02-26
Rated 5 out of 5 by from Great Results! I have been using this Retinol 0.5 about once to twice a week and i have been using this for about a year now. I love how this product works. My skin Glows so much! I'm so glad i found this product
Date published: 2019-01-25
Rated 4 out of 5 by from Been using for 2 months 25 years old, went in guns blazing with this, using every night as a part of my nightly regimen. It makes my skin feel so good and smooth immediately after using it. I've noticed a little improvement in forehead lines but its only been two months so we'll see. I thought it would help my large pores/blackheads on my nose but it really hasn't at all. I know it takes time so I'll stick with it and maybe bump to the 1.0 after this one finishes. Did not have any redness/peeling/drying like other reviewers at all.
Date published: 2019-01-06
Rated 1 out of 5 by from I didn’t see results so far I bought this product when my skin and acne was really better (I used 2 bottles of Blemish + Age defense serum and LHA cleanser and toner), because they were good to acne and skin tone but not to blackheads. I thought Retinol would help me with this problem and I read about 3 months to effect.. but it was aggressive product to my skin, and acne came back strong probably because I stopped other products (as recommended). I just used twice a week, sometimes once a week but it was bad as well. Now I will keep using on forehand, to see because this is the only part of my face that didn’t have problems.
Date published: 2018-11-17
Rated 5 out of 5 by from Lightens dark spots from melasma I bought this about two months ago. It is very strong and i use only once or twice a week. It does make my skin peel as it should. It is slowly taking away the brown from my melasma. I recommend this highly. I am anxious to try the rest of their products.
Date published: 2018-11-16
Rated 4 out of 5 by from Great product I have been applying it every other night since July. I see the difference on my skin.
Date published: 2018-10-08
Rated 5 out of 5 by from Best Treatment I've Found I have been suffering from acne since I was 13 (now 26). After a respite in my early 20s I had resurgence after changing birth control. I tried everything in the drug store and natural remedies; they would work for a few weeks and then ultimately stop working. My mom suggested the Retinol 0.5 cream to me after she noticed it helped with her blemishes (she used it for anti-aging). While this is more than I was comfortable spending I was desperate. After a week I saw a dramatic difference in my skin, after 2 weeks all of my pimples were completely gone (there are still sometimes new ones, but they're small and go away after a day or two). After 3-4 weeks of using this product, not only did my skin become more clear than I have ever seen it get in my life, but my old acne scars - ones which I had had for YEARS - were going away. I have been using this product now for about 7 months and I cannot recommend it highly enough. I have even gotten a few of my friends turned onto it for their skin ailments and they have all also seen incredibly positive results. My only complaint is that I wish there was more of it in each tube! But I am still giving it 5 stars.
Date published: 2018-10-08
Rated 5 out of 5 by from Works Great! I just started with Retinol 0.5% 2 months ago. My skin looks firmer and clearer. I read that Retinols take time to work. I believe it will show better results as I adjust with how often I apply it. I started using it 3x a week and now I use it every other night. I use H.A Intensifier after to help with the flakiness and dryness at night. I use C E Ferulic acid and the tinted SPF 50 of Skinceuticals in the morning. I have not used foundation for 2 months now since I started with my Skinceuticals routine. I use mascara, eyeliner, bronzer, lipstick with only spf under and I look great and glowing. I will be getting the triple lipid restore when I start using this retinol 0.5 every night in conjunction with all my Skinceuticals products. So far, I’m very happy with the results. I will be getting the 1% once I’m done with my .5%.
Date published: 2018-08-10
Rated 5 out of 5 by from 29/m I love it, I've been using it for 8 months to help large pores in my t-zone. I started by using it twice per week, then every other night, and now almost every night. If you notice redness or flaking, slow down and use it less. You'll get there, it just takes time. After six months, my pores looked less deep, so I just bought my second tube of 0.5.. and in another 8 months maybe I'll be able to bump up to the 1.0.
Date published: 2018-06-04
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