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Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 504.
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A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

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Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types

Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Apply a small amount between fingertips, warm and melt the cream in circular motions. Apply once or twice daily to face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before


    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof

  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

Physician image

I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen


Rated 5 out of 5 by from Best product ever I love this product. Every bit worth the money. Would not use anything else.
Date published: 2020-04-18
Rated 5 out of 5 by from Happy customer! I never bought anti aging creams and was overwhelmed when I started my research. I have eczema and sensitive skin, so I’m always leery about new products but I’m really happy with this purchase! Within a month, I already see a difference.... my wrinkles seem a little less and my skin feels very hydrated!
Date published: 2020-04-11
Rated 5 out of 5 by from Very rich and moisturizing I love this product. It's super rich and moisturizing! Helped get rid of my flaky skin.
Date published: 2020-04-10
Rated 5 out of 5 by from Great product! I am 42 years old and I have been taking care of my skin since I was 25. I have been using Skinceuticals for the last 6 years and I am extremely happy with their products. I only have fine lines on the outer corner of my eyes that shows when I smile and on my forehead that shows when I lift my eyebrows. Although there is no miracle product that will permanently erase those fine lines, this product definitely helps nourish my skin, making my skin look healthier and most importantly preventing those fines lines from becoming deep wrinkles. I use this product twice a day , it has a thick consistency , but it absorbs quickly. All my skin care products are from skinceuticals, they work really good together and I trust the science behind it.
Date published: 2020-02-24
Rated 5 out of 5 by from I love it I bought this item due to the love of Skinceuticals. I really liked the texture and weight of this moisturizer doesn't feel greasy, a little goes a long way and I will continue to use!
Date published: 2020-02-15
Rated 5 out of 5 by from Love everything about it! I am not a person who is impressed with “hype” and unfounded claims about a product and never write reviews because I am usually disappointed with most products. However, I thought I would splurge and give myself a gift and purchased this because my skin has become dry and wrinkly looking as I am an aging woman. I have used this cream everyday for about one month without any other skin care treatment on my face except my daily makeup and foundation. I can honestly say I have seen a decrease in fine lines and wrinkles especially under my eyes as it is also a wonderful eye cream. I love it’s scent which is fresh and clean and I look forward to putting it on my face everyday. It is not greasy and I use a lot because I just love it. My skin looks smoother and firmer and my pores are smaller which was a nice surprise. I do have some old acne scars on my face which it has not helped but I know it was not meant to. I will definitely be purchasing again!
Date published: 2020-02-10
Rated 5 out of 5 by from BEST PRODUCT FOR DRY SKIN This product was recommended to me by my esthetician when I was on Accutane. If you don’t know, accutane can make your skin severely dry and flaky to the point where no moisturizer was doing the do job. I would have chunks of skin falling off during work and then my skin would get red and irritated because I’d be trying to scrape it off to make it look better. This product along with the phyto corrective gel & masque worked wonders. It helped me tremendously while on accutane and afterwards. I continued to use this product years later. After one use on a dry patch, your skin will be glowing and moisturized like you’ve never seen before. I’m an esthetician and I use numerous product lines but Skin Ceuticals will always be my favorite.
Date published: 2020-01-31
Rated 5 out of 5 by from Great product I needed some more moisturizer and was t really impress .. I use the c-serum brightener and been very happy so after reading reviews I decided to try the lipid restore .. 2.5 weeks user and will continue w my skin regime .. highly recommend .. skin is silky , Dewey :) perfect .. 47 yrs young
Date published: 2020-01-19
Rated 5 out of 5 by from Best night cream ever! I received a sample of this cream and almost ended up giving it to my mom as after going over the ingredients, I thought it'd be more suited for her mature skin. However, I've heard good things about SkinCeuticals and decided to give it a try myself. I'm so glad I did! This cream was my introduction to the brand. I woke up and just kept looking at myself in a mirror because my skin looked so good. In fact, I thought how much younger I looked. A lot of creams leave my skin greasy in the morning, but not this one. My skin looked plump, it was soft, my pores seemed smaller and my number 11s were not as profound. I have combination skin and this cream did not make it greasy at all. Even when I apply it, my skin looks more matte. There was no irritation, no breakouts and it has a very pleasant herbal lavender scent which is in no way strong at all. So, those who are sensitive to smells, rest assure. I would even describe the scent as soothing and calming. Perhaps due to lavender. I then spent quite sometime educating myself about the brand and the products. Although I'm in my mid 30s, I didn't know that there were medical grade skincare and regular beauty stores skincare. Ever since trying SkinCeuticals, I stopped using whatever I've accumulated at skincare/makeup retailers at Malls and other places. With SkinCeuticals I noticed immediate results. After a few more uses, I realized that I could not live without this night cream. So, I bought a night cream and a serum. Fast forward a month later, most of my skincare now consists of SkinCeuticals. Why!?! Because I see results. My skin hasn't looked this good since I was in my 20s. I would rather have two products that work than a graveyard of cremes that don't. My. mom's birthday is coming up, and I will be getting her some SkinCeuticals products as well because they are simply amazing!
Date published: 2020-01-18
Rated 5 out of 5 by from From scaly to dewy skin I discovered this moisturizer and have been using it daily for 10 months (I have run out and am here to order more). I have AWFUL skin to start with: it is sensitive, I get bouts of cystic acne (I am 27), it's dry, and it looks transparent and discolored. The final straw was last winter when my cheeks got so dry that it became scaly and inflamed. I heard of this moisturizer via a makeup artist and decided to invest in it. BEST choice I've made. The scaliness and redness disappeared and my skin tone evened out to a more uniform color and appeared more plump. Best part is it doesn't irritate my acne in any way. Can't live without this product!
Date published: 2020-01-06
Rated 5 out of 5 by from Dewy skin again This, along with the Serum 10 AOX+, has made an incredible difference in my skin. My dry skin with fine wrinkles becomes smooth and dewy with a little bounce. I have very sensitive skin, and I have had no problems with either product. I first tried the Emollience cream and may try it again during the summer, but it was not enough for winter dry skin.
Date published: 2020-01-01
Rated 5 out of 5 by from AMAZING!!! I love this product SO much! I have been using this for more than a year now and can tell a HUGE change in my skin. My skin is so much more smoother and softer. I love the way it smells too! Thank you for making such a wonderful product.
Date published: 2020-01-01
Rated 5 out of 5 by from Product that delivers results I have been using Triple Lipid Restore 2:4:2 for three weeks. My skin has improve already. Much smoother like a baby face and foundation looks better. Also, fine lines and wrinkles are reducing. It is not greasy and has a relaxing scent much like peppermint. Makes me want to apply it all over my body. Definitely we continue to use this product. I have been using SkinCeuicals Physical Fusion UV Defense for a year, recommended by my dermatologist due to sun damage. Next product will be C E Ferulic.
Date published: 2019-12-22
Rated 5 out of 5 by from Obsessed with this! I love this product! I use it at night as lotion and sometimes during the day under my regular sunscreen/moisturizer. My skin can be dry in the winter and this product always helps. A little goes a long way. I will only be using this from now on. Already on my second bottle.
Date published: 2019-12-18
Rated 5 out of 5 by from Great!!! Amazing!!! Every night and in 2 weeks you will see the difference
Date published: 2019-12-17
Rated 5 out of 5 by from 2nd bottle I have started my second bottle and love this cream. Very moisturizing without being greasy and my skin looks plump
Date published: 2019-11-25
Rated 5 out of 5 by from Happy I think this is one of my favorite creams ever! I have dry sensitive skin and this feels amazing. I can't wait to put it on in the evening. The texture, thickness, and smell. I am very sensitive ti smell. This just has a light refreshing clean smell and feel! Worth very penny.
Date published: 2019-11-18
Rated 5 out of 5 by from Amazing product Very pleased with this product. It was a recommendation from a friend. After a few days of use, my co-worker noticed a difference with my skin. I used it every day in the winter!
Date published: 2019-11-18
Rated 5 out of 5 by from Best moisturizer I have ever used. Wonderful moisturizer. Exactly what I’ve been looking for! Make my face feel nurtured, soft and well cared for.
Date published: 2019-10-10
Rated 1 out of 5 by from Very disappointed I will preface this review by saying that I have been using skin ceutical products since 2002. I love their antioxidents. I have been using the CE Feurlic and Hydrating B5 gel since 2002, and have recommended those products to friends. Several years ago, I switched products briefly and went to another line because the asthetician I was seeing suggested changing skin care lines from time to time. I came back to skin ceuticals within a month and have not changed since. After using the CE feurlic for so many years in my daytime regime, I recently purchased the Resveratrol BE for nighttime use. I needed a moisterizer to pair with this product. I had a sample of the AGE Interrupter and tried it with the BE. I did not get the hydration I needed from the AGE, so I bought the Triple Lipid Restore based, in part, on the reviews, and, in part, on the recommendation of a customer care representative. I really wanted to like this product, and was expecting to like it given the high cost and my experience with other skin ceutical products. However, I was very disappointed. It did not absorb into my skin, and I left it on all night. So I gave it ample time. When I woke up in the morning the cream felt sticky and thick on my face. It seemed like a cheap product that one would buy at a low end department store. It was not the same quality as the other skin ceutical products I have used. I have returned this product.
Date published: 2019-08-31
Rated 5 out of 5 by from A boon to my skin - love it! I recently added Triple Lipid Restore 2:4:2 to my skin care regimen - I have aging skin and needed a good moisturizer to go with C E Ferulic and Hyaluronic Acid Intensifier - and Triple Lipid Restore is so creamy and nourishing and feels so good, and doesn't dry my skin (A.G.E. Interrupter did not work well for me--too drying). I highly recommend it for drier, aging skin.
Date published: 2019-08-09
Rated 5 out of 5 by from LOVE LOVE LOVE Hands down the best SkinCeuticals product in my opinion! I've been using it for 2 years now and have had amazing results! My skin is oily but this evens out my skin tone/texture and gives me just enough moisture without over doing it.
Date published: 2019-07-24
Rated 5 out of 5 by from Beat face cream I’ve ever used! I’ve been using this face cream for 6 months but saw changes to my skin within the first month. It’s the only face cream that ever shrunk my pokes and keeps my skin tight
Date published: 2019-07-03
Rated 5 out of 5 by from Great Moisturizer with Results! I use this in the AM after my applying my CE Ferulic and before my sunscreen and again at night when I do not use the Glycolic 10 product. Perfect moisturizer. Keeps skin balanced and hydrated. Really improved overall hydration and skin condition. Worth the price!
Date published: 2019-07-03
Rated 5 out of 5 by from Great I am glad I bought this product, it works great. My skin tone more even now. It worth the price.
Date published: 2019-06-22
Rated 5 out of 5 by from It Works I first purchased the Triple Lipid Restore Cream 9 months ago. Totally pleased with the results, the surface texture of my skin has changed, so much smoother! The deeper lines have decreased. Plan to continue this product.
Date published: 2019-06-10
Rated 5 out of 5 by from My Holy Grail This is my third jar of this stuff and it is a must have in my day to day! I have very dry, mature skin and this is a lifesaver. Makes my skin feel amazing and keeps it plump and moisturized. It is pricey...but my skin loves this stuff and I can't live without it! Note*** It is absolutely wonderful after any kind of facial treatment, if your using a retinoid, or even derma rolling.
Date published: 2019-06-09
Rated 5 out of 5 by from Best Cream for Sensitive Skin I have extremely sensitive skin. I have been using another brand for more than 10 years, which is gentle but not enough for me any more when it comes to my 30s. Triple Lipid is my first Skin Ceuticals product. I talked to my specialist about the inflammation after treatment and she recommended this cream for my specific concern. It is very gentle that I can use it right after facial treatment. I can feel my skin is hydrated and at the same time the inflammation lasts short since I use this cream (Usually, it takes 4 days to recover, but it takes only one to two days for me now). Since it helped my inflammation, I started replacing it as my daily moisturizer. After about two weeks, I can totally tell my skin is getting stronger not just improvement in pore or smoothness. BUT, I don't get redness at the end of day. I don't have to worry itchy skin or rash after walking under the sun or in the garden as much any more. It does not only moist the skin when one applies it. It does improve the skin itself. Highly recommended!
Date published: 2019-06-09
Rated 5 out of 5 by from Highly recommend for daily skin maintenance I have been using 2:4:2 for 3-4 years now. I was first introduced to this product via a plastic surgeons office. It has worked wonders for me. It has assisted in preventing wrinkles and providing hydration to my skin. It is light and does not block pores.
Date published: 2019-06-09
Rated 5 out of 5 by from Great moisturizer! I’ve been using triple lipid restore for the past couple of years, and it is one of my ‘must haves’ In my skin care regimen. It relieves my dry skin due to aging, as well as relief from occasional sunburns. I highly recommend this product especially when using the retinol products. Along with the AGE eye cream, this product has greatly improved my fine lines.
Date published: 2019-06-09
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