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Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 489.
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A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

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Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types

Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Once or twice daily, apply a small amount between fingertips, warm and melt the cream in circular motions. Apply twice daily to on face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before


    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof

  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

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I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen


Rated 5 out of 5 by from Love it!! I will soon be 70 and since I have been using SkinCeuticals products my skin is just amazing.I will try to add a photo to show how much this particular cream has improved the moisture and diminished the wrinkles in my cheek area. It has really plumped it up. I just love this Lipid Restore cream. I have not mastered the art of selfies as you can tell!! Please, if you have aging skin that is dry and looks like you have lost some of the fullness in your cheek area, you will not be disappointed with this cream.
Date published: 2018-12-01
Rated 5 out of 5 by from My Favorite Products I am 70 years old and ever since I started using Skin Ceutical Products years ago, I am told my skin looks like porcelain. My two favorite products are the CE Ferulic Serum, Triple Lipid Restore cream which I use in the AM and PM, and the tinted sunscreen which I wear every day under my foundation. Products are a little pricey but well worth the money spent. I am a lifetime customer.
Date published: 2017-05-02
Rated 5 out of 5 by from A boon to my skin - love it! I recently added Triple Lipid Restore 2:4:2 to my skin care regimen - I have aging skin and needed a good moisturizer to go with C E Ferulic and Hyaluronic Acid Intensifier - and Triple Lipid Restore is so creamy and nourishing and feels so good, and doesn't dry my skin (A.G.E. Interrupter did not work well for me--too drying). I highly recommend it for drier, aging skin.
Date published: 2019-08-09
Rated 5 out of 5 by from The Best Moisturizer After treatment I had really dry skin. So my specialist put this product on my face and immediately I felt the difference. My face felt so hydrated therefore, I end up buying the cream right there and there. For a week I used it Day and night. My face looked radiant no matter how tired I was. My wrinkles are not as prominent, my skin feels so supple and smooth. I can’t live without it. I immediately told my specialist how much of a difference it had made on my skin. I am so glad she introduced this to me. I always buy the most expensive skin care but none of it does what this cream can do. It’s light, it’s motivating to see my skin glow once again. Awesome! Awesome! Product. Last note: I have melasma and my melasma have improved, the darkness has gotten lighter and my skin improved overall.
Date published: 2019-05-15
Rated 5 out of 5 by from Hydration heaven I have extremely dry skin so hydration is the number one factor I look for when choosing skin care products. I love that it absorbs quickly into th skin but doesn’t disappear. My skin is hydrated, soft and smooth all day! I also mix this into my Dermablend Flawless Creator Foundation and it’s pure magic! I apply the HA intensifier first then combine two drops of the foundation with a couple drops of this nourishing cream and apply as usual with my beauty blender and voila! The fact that it meets dermatologist standards has a lot to do with the amazing quality. This combo is simply perfection! I am 100% impressed! HIGHLY RECOMMEND! I will most definitely be including this in a YouTube video very soon!
Date published: 2017-12-01
Rated 4 out of 5 by from Great product wrong packaging I’m a 41 years old woman with dry combination, acne prone skin. I really like this product it’s rich but dries fast and live my skin feeling hidrated and silky soft. It Plays really well under makeup. It has amazing ingredients the only downside to it for me is the packaging it’s an open jar and the ingredients won’t last long once it gets in contac with the oxigen, light and fingers. It has a pleasant fragrance but it strong and I’m afraid it can irritate sensitive skin due to essential oils. It’s a well thought product with the best ingredients and I like it. Please change the packaging for an airtight frosted jar with a pump.
Date published: 2018-01-08
Rated 5 out of 5 by from Ultra moisturizing! I’m 25 years old, even tho my primary concern is not anti-aging, I’m aware that start using this kind of products is very beneficial for your skin! I have combination skin and huge pores. I could notice that using this moisturizer along with the new Hyaluronic Acid Intensifier, my pores looked smaller and a firmer looking skin speacially in the cheeks area. Beside that it’s ultra moisturizing and it feels nice now in the winter. Definitely I recommend it for elder women or young women who want to start an anti-aging routine. I received this product as a free sample for testing.
Date published: 2017-12-20
Rated 5 out of 5 by from THIS WORKS! IT'S JUST NOT FOR ME I am 28 and have many skin concerns...acne, scarring, hyper pigmentation, fine lines, uneven tone, and the most prominent - sensitivity. I used this triple lipid restore and I started noticing a difference in all of my skin ailments...with one exception... I am incredibly sensitive to cream moisturizers. The only ones that *rarely* work for me are gels. This product, despite all of it's benefits, did leave me with very small pimples on forehead. I do NOT blame the product or the company. It truly is just what typically happens to my skin when I use moisturizers. If you have less sensitive skin than I do (which isn't difficult!) I think you will love this product!
Date published: 2018-01-12
Rated 5 out of 5 by from It Works I first purchased the Triple Lipid Restore Cream 9 months ago. Totally pleased with the results, the surface texture of my skin has changed, so much smoother! The deeper lines have decreased. Plan to continue this product.
Date published: 2019-06-10
Rated 3 out of 5 by from Creamy texture, matte finish I received a complimentary sample of this product in a Voxbox. The sample was about 4 days' worth of product, so I used it morning and night along with the Hyaluronic Skin Intensifier in lieu of my usual skincare routine. The cream was rich and thick, though I didn't notice a significant difference in moisture levels and often felt like I wanted to use my regular moisturizer on top of it. The product did leave a nice matte finish, though, so if you want moisture but are worried about shine, I think it would be good. I appreciated getting to try out the sample, but it's not something I would repurchase.
Date published: 2017-12-05
Rated 5 out of 5 by from LOVE LOVE LOVE Hands down the best SkinCeuticals product in my opinion! I've been using it for 2 years now and have had amazing results! My skin is oily but this evens out my skin tone/texture and gives me just enough moisture without over doing it.
Date published: 2019-07-24
Rated 4 out of 5 by from Triple lipid The coverage and feel of this foundation is amazing. It’s literally weightless and leaves your skin with a natural finish. The coverage is incredible, though it’s most definitely full coverage it leaves your skin looking as if it is your own. My only complaint is that it does cling to dry patches. I tend to have dryer skin in the winter and unless I exfoliate more often this could resent a problem for me wearing it. Otherwise this is a great foundation with an admirable shade range. I did receive this product as a free sample in exchange for an honest and thoughtful review. I received this product complimentary for review purposes.
Date published: 2018-01-12
Rated 5 out of 5 by from My HG Moisturizer At this point I have lost count of how many different moisturizers I have tried for my oily/dehydrated skin. All moisturizers make me look like an oil slick within 1-2 hours, requiring blotting my entire face several times throughout the day. Some leave a sheen on my face I cant even blot off. I am dark skinned, so oil is much more noticeable on my skin and can make it look dull. Triple Lipid Restore has been such a surprising find. I expected it to be very heavy and oily. But its a great moisturizer that truly hydrates, plumps up fine lines, and seems to prevents TEWL. It absorbs well and leave a matte finish. My skin looks like it has an inner glow. I also think it has decreased/prevented oil overproduction. I have to blot my nose once mid day and that's it. I save it for the mornings or nights out because 1. its expensive and 2. it does not make my face oily. I don't care how I look going to bed. It also wears well under makeup. One recommendation/request I have to the brand would be for an airless pump packaging. Otherwise it is overall a great product.
Date published: 2018-12-14
Rated 5 out of 5 by from Great Moisturizer with Results! I use this in the AM after my applying my CE Ferulic and before my sunscreen and again at night when I do not use the Glycolic 10 product. Perfect moisturizer. Keeps skin balanced and hydrated. Really improved overall hydration and skin condition. Worth the price!
Date published: 2019-07-03
Rated 5 out of 5 by from Great Product First off I would like to say that I love this product. I have pretty decent skin so really my purpose was to use this as a moisturizer. I have combination skin and most moisturizers make my skin extra oily looking after 2 hours. I don't mind a little glow but if I'm looking like a bucket of grease was poured on my face then its a problem. I have tried many products like this and when I say this is number 1, it's just that good. Honestly, when I saw the price for this cream I was shocked it was as expensive as it is but id say if you have the money to splurge then go for it.
Date published: 2018-02-01
Rated 5 out of 5 by from Best Cream for Sensitive Skin I have extremely sensitive skin. I have been using another brand for more than 10 years, which is gentle but not enough for me any more when it comes to my 30s. Triple Lipid is my first Skin Ceuticals product. I talked to my specialist about the inflammation after treatment and she recommended this cream for my specific concern. It is very gentle that I can use it right after facial treatment. I can feel my skin is hydrated and at the same time the inflammation lasts short since I use this cream (Usually, it takes 4 days to recover, but it takes only one to two days for me now). Since it helped my inflammation, I started replacing it as my daily moisturizer. After about two weeks, I can totally tell my skin is getting stronger not just improvement in pore or smoothness. BUT, I don't get redness at the end of day. I don't have to worry itchy skin or rash after walking under the sun or in the garden as much any more. It does not only moist the skin when one applies it. It does improve the skin itself. Highly recommended!
Date published: 2019-06-09
Rated 5 out of 5 by from Product that delivers results I have been using Triple Lipid Restore 2:4:2 for three weeks. My skin has improve already. Much smoother like a baby face and foundation looks better. Also, fine lines and wrinkles are reducing. It is not greasy and has a relaxing scent much like peppermint. Makes me want to apply it all over my body. Definitely we continue to use this product. I have been using SkinCeuicals Physical Fusion UV Defense for a year, recommended by my dermatologist due to sun damage. Next product will be C E Ferulic.
Date published: 2019-12-22
Rated 5 out of 5 by from Triple Liquid Restore 2:4:2 - Fabulous! I have been looking to replace the SkinMedica Essential Serum with something from SkinCeuticals because I trust the product line and the Essential Serum became so expensive. I ordered this along with the new Hyaluronic Acid Intensifier. So far I’ve had wonderful results with this combination and am now exploring the site for more products to work on fine lines and elasticity. My mom has a history of melanoma skin cancer so I am very careful in choosing what I use… So far, this has been a fabulous combination! Try it, you’ll see for yourself….
Date published: 2017-06-17
Rated 5 out of 5 by from Wonderful product This is the best moisturizer I ever used!! My skin is very sensitive and acne prone. This cream helped clear my acne and blemishes. It is very soothing and leaves your skin soft. It also helps with hyperpigmentation and uneven skin tone. Can't say enough good things about this product. Absolutely in love with it!
Date published: 2016-03-24
Rated 5 out of 5 by from Immediate Improvement I received this product as a free sample through Influenster. I quit my regular face routine and starting using a Skinceuticals routine a week ago. After the first night I noticed an improvement in the redness in my face. I feel like it’s helping to create a much better foundation for my makeup as well. I’ve received several compliments on my skin this week. This product goes on really smooth and the smell nice too. I’m anxious to see even more important in my skin in the next few weeks. I would definitely buy this product and I’d like to try more of the products.
Date published: 2017-12-02
Rated 5 out of 5 by from So moisturising! I've got quite dry skin (coffee lover, and no, I don't ever drink enough water) and this was like a dream to wear. Along with the HA intensifier drops my skin felt absolutely amazing! I received it as a complimentary sample and am seriously considering buying the full size. It's just THAT good. Only, I'm a little turned off by the price, as I usually only spend around $50 on a moisturiser. But I guess it's worth it for real results! The consistency was great, it felt medium - heavy which I prefer for my skin over gels, it's just that much more comforting when your skin feels like it will crack.
Date published: 2018-01-04
Rated 5 out of 5 by from Best Moisturizer I’ve ever Used Although this skin cream is very expensive, it’s worth it. After a couple of months of using it, my skin feels soft, looks rosy, and the fine lines around my mouth are much less visible. In addition, my neck looks dramatically smoother. Highly recommended!
Date published: 2019-03-16
Rated 5 out of 5 by from My Holy Grail This is my third jar of this stuff and it is a must have in my day to day! I have very dry, mature skin and this is a lifesaver. Makes my skin feel amazing and keeps it plump and moisturized. It is pricey...but my skin loves this stuff and I can't live without it! Note*** It is absolutely wonderful after any kind of facial treatment, if your using a retinoid, or even derma rolling.
Date published: 2019-06-09
Rated 4 out of 5 by from Feels Great on Skin I received a (very) small sample size in exchange for an honest review. I used the entire product along with the serum I received in hopes of noticing a difference in my skin. As I near 30 I’m getting concerned with aging and have been looking for great skin care products/regimes. Unfortunately, I didn’t notice a real difference in my skin after using this. It was very nice rich texture, absorbed well on my skin, had no weird smell, etc. but I don’t think I was able to use it long enough to see any results. My skin was a bit broken out during the use, I don’t think it was FROM this product, but that may have been part of the issue with not seeing/noticing positive results.
Date published: 2018-01-19
Rated 1 out of 5 by from Very disappointed I will preface this review by saying that I have been using skin ceutical products since 2002. I love their antioxidents. I have been using the CE Feurlic and Hydrating B5 gel since 2002, and have recommended those products to friends. Several years ago, I switched products briefly and went to another line because the asthetician I was seeing suggested changing skin care lines from time to time. I came back to skin ceuticals within a month and have not changed since. After using the CE feurlic for so many years in my daytime regime, I recently purchased the Resveratrol BE for nighttime use. I needed a moisterizer to pair with this product. I had a sample of the AGE Interrupter and tried it with the BE. I did not get the hydration I needed from the AGE, so I bought the Triple Lipid Restore based, in part, on the reviews, and, in part, on the recommendation of a customer care representative. I really wanted to like this product, and was expecting to like it given the high cost and my experience with other skin ceutical products. However, I was very disappointed. It did not absorb into my skin, and I left it on all night. So I gave it ample time. When I woke up in the morning the cream felt sticky and thick on my face. It seemed like a cheap product that one would buy at a low end department store. It was not the same quality as the other skin ceutical products I have used. I have returned this product.
Date published: 2019-08-31
Rated 5 out of 5 by from Highly recommend for daily skin maintenance I have been using 2:4:2 for 3-4 years now. I was first introduced to this product via a plastic surgeons office. It has worked wonders for me. It has assisted in preventing wrinkles and providing hydration to my skin. It is light and does not block pores.
Date published: 2019-06-09
Rated 5 out of 5 by from Left my skin feeling refreshed and soft! I received a complimentary sample of the SkinCeuticals Triple Lipid Restore 2:4:2 and let me tell you, I loved it! The first thing I noticed was that the product had a nice, non-greasy and lightweight texture and application which is super important to me because I want to make sure my skin feels like it can breath, and I was able to use this product day and night. I have extremely dry and sensitive skin,and I live in Utah where my skin is effected by the harsh winters so I'm always looking for extreme facial moisturizers, this product did the trick. My skin felt hydrated, refreshed, and soft even after a long day out at school and work. I would certainly recommend this as a top anti-aging creme!
Date published: 2018-01-12
Rated 5 out of 5 by from I love SkinCeuticals! I have been using CE Ferulic since 2005 and I would not be without it. I am 65 and my skin looks really good for my age (I am told). I received a sample of Triple Lipid Restore 2:4:2 about three months ago, and I love it! I used to use Clinique Dramatically Different moisturizer with the CE Ferulic each morning, but since discovering how well the Triple Lipid Restore 2:4:2 worked and how it makes my skin look, I am now using it with my CE Ferulic each day. Yes, it's expensive too, but I look at it this way: I am 65 and have not had any work done to my face. With the combination of these two excellent products, I may not need to in the future. Anyway, that is my hope! I want to add that I realize Clinique Dramatically Different moisturizer is not in the same league as SkinCeutical’s Triple Lipid Restore, but I just like the way the Triple Lipid Restore 2:4:2 makes my face look and feel over the Clinique Dramatically Different moisturizer, which by the way, is an excellent product for what it has to offer.
Date published: 2018-02-28
Rated 3 out of 5 by from Ok but not amazing I love skinceuticals and I believe in the integrity and intention of their products. I have combination skin that has gotten significantly dryer as I get older. My biggest problem area is my forehead which alternates between dry and oily with some fine lines. When it comes to triple lipid restore cream I love the texture and the way it applies evenly to my skin and moisturizes throughout. It does an excellent job of evening out the moisture levels on my entire face. So all in all I really like it. The only problem I have is that the cream is good but not exceptional. In a very competitive industry I expect a product of this price to have a dramatic effect. The best results seem to only come from using this in tandem with another very expensive product. To me that is over the top and unnecesssary. There are many products out there with equal results and quality for a fraction of the price.
Date published: 2018-01-26
Rated 2 out of 5 by from Not the best product for me I have been using this for about 2 weeks, since I run out of my other day mosturizer and decided to try this instead. It mosturizes just like my old one, yet does nothing better. So I am not thrilled to buy another jar once it is finished.
Date published: 2019-06-08
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