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Triple Lipid Restore 2:4:2 Anti aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 409.
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Anti aging treatment cream to refill cellular lipids and nourish dry skin

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Product Details

Triple Lipid Restore 2:4:2 is an anti aging cream formulated with a maximized concentration of lipids: 2% pure ceramides, 4% natural cholesterol, and 2% fatty acids. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types

Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Once or twice daily, apply a small amount between fingertips, warm and melt the cream in circular motions. Apply twice daily to on face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before


    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof

  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

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I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen


Rated 5 out of 5 by from My Favorite Products I am 70 years old and ever since I started using Skin Ceutical Products years ago, I am told my skin looks like porcelain. My two favorite products are the CE Ferulic Serum, Triple Lipid Restore cream which I use in the AM and PM, and the tinted sunscreen which I wear every day under my foundation. Products are a little pricey but well worth the money spent. I am a lifetime customer.
Date published: 2017-05-02
Rated 3 out of 5 by from Creamy texture, matte finish I received a complimentary sample of this product in a Voxbox. The sample was about 4 days' worth of product, so I used it morning and night along with the Hyaluronic Skin Intensifier in lieu of my usual skincare routine. The cream was rich and thick, though I didn't notice a significant difference in moisture levels and often felt like I wanted to use my regular moisturizer on top of it. The product did leave a nice matte finish, though, so if you want moisture but are worried about shine, I think it would be good. I appreciated getting to try out the sample, but it's not something I would repurchase.
Date published: 2017-12-05
Rated 5 out of 5 by from THIS WORKS! IT'S JUST NOT FOR ME I am 28 and have many skin concerns...acne, scarring, hyper pigmentation, fine lines, uneven tone, and the most prominent - sensitivity. I used this triple lipid restore and I started noticing a difference in all of my skin ailments...with one exception... I am incredibly sensitive to cream moisturizers. The only ones that *rarely* work for me are gels. This product, despite all of it's benefits, did leave me with very small pimples on forehead. I do NOT blame the product or the company. It truly is just what typically happens to my skin when I use moisturizers. If you have less sensitive skin than I do (which isn't difficult!) I think you will love this product!
Date published: 2018-01-12
Rated 4 out of 5 by from Great product wrong packaging I’m a 41 years old woman with dry combination, acne prone skin. I really like this product it’s rich but dries fast and live my skin feeling hidrated and silky soft. It Plays really well under makeup. It has amazing ingredients the only downside to it for me is the packaging it’s an open jar and the ingredients won’t last long once it gets in contac with the oxigen, light and fingers. It has a pleasant fragrance but it strong and I’m afraid it can irritate sensitive skin due to essential oils. It’s a well thought product with the best ingredients and I like it. Please change the packaging for an airtight frosted jar with a pump.
Date published: 2018-01-08
Rated 5 out of 5 by from Hydration heaven I have extremely dry skin so hydration is the number one factor I look for when choosing skin care products. I love that it absorbs quickly into th skin but doesn’t disappear. My skin is hydrated, soft and smooth all day! I also mix this into my Dermablend Flawless Creator Foundation and it’s pure magic! I apply the HA intensifier first then combine two drops of the foundation with a couple drops of this nourishing cream and apply as usual with my beauty blender and voila! The fact that it meets dermatologist standards has a lot to do with the amazing quality. This combo is simply perfection! I am 100% impressed! HIGHLY RECOMMEND! I will most definitely be including this in a YouTube video very soon!
Date published: 2017-12-01
Rated 4 out of 5 by from Feels Great on Skin I received a (very) small sample size in exchange for an honest review. I used the entire product along with the serum I received in hopes of noticing a difference in my skin. As I near 30 I’m getting concerned with aging and have been looking for great skin care products/regimes. Unfortunately, I didn’t notice a real difference in my skin after using this. It was very nice rich texture, absorbed well on my skin, had no weird smell, etc. but I don’t think I was able to use it long enough to see any results. My skin was a bit broken out during the use, I don’t think it was FROM this product, but that may have been part of the issue with not seeing/noticing positive results.
Date published: 2018-01-19
Rated 4 out of 5 by from Triple lipid The coverage and feel of this foundation is amazing. It’s literally weightless and leaves your skin with a natural finish. The coverage is incredible, though it’s most definitely full coverage it leaves your skin looking as if it is your own. My only complaint is that it does cling to dry patches. I tend to have dryer skin in the winter and unless I exfoliate more often this could resent a problem for me wearing it. Otherwise this is a great foundation with an admirable shade range. I did receive this product as a free sample in exchange for an honest and thoughtful review. I received this product complimentary for review purposes.
Date published: 2018-01-12
Rated 5 out of 5 by from So moisturising! I've got quite dry skin (coffee lover, and no, I don't ever drink enough water) and this was like a dream to wear. Along with the HA intensifier drops my skin felt absolutely amazing! I received it as a complimentary sample and am seriously considering buying the full size. It's just THAT good. Only, I'm a little turned off by the price, as I usually only spend around $50 on a moisturiser. But I guess it's worth it for real results! The consistency was great, it felt medium - heavy which I prefer for my skin over gels, it's just that much more comforting when your skin feels like it will crack.
Date published: 2018-01-04
Rated 5 out of 5 by from Wonderful product This is the best moisturizer I ever used!! My skin is very sensitive and acne prone. This cream helped clear my acne and blemishes. It is very soothing and leaves your skin soft. It also helps with hyperpigmentation and uneven skin tone. Can't say enough good things about this product. Absolutely in love with it!
Date published: 2016-03-24
Rated 5 out of 5 by from Triple Liquid Restore 2:4:2 - Fabulous! I have been looking to replace the SkinMedica Essential Serum with something from SkinCeuticals because I trust the product line and the Essential Serum became so expensive. I ordered this along with the new Hyaluronic Acid Intensifier. So far I’ve had wonderful results with this combination and am now exploring the site for more products to work on fine lines and elasticity. My mom has a history of melanoma skin cancer so I am very careful in choosing what I use… So far, this has been a fabulous combination! Try it, you’ll see for yourself….
Date published: 2017-06-17
Rated 5 out of 5 by from Left my skin feeling refreshed and soft! I received a complimentary sample of the SkinCeuticals Triple Lipid Restore 2:4:2 and let me tell you, I loved it! The first thing I noticed was that the product had a nice, non-greasy and lightweight texture and application which is super important to me because I want to make sure my skin feels like it can breath, and I was able to use this product day and night. I have extremely dry and sensitive skin,and I live in Utah where my skin is effected by the harsh winters so I'm always looking for extreme facial moisturizers, this product did the trick. My skin felt hydrated, refreshed, and soft even after a long day out at school and work. I would certainly recommend this as a top anti-aging creme!
Date published: 2018-01-12
Rated 3 out of 5 by from Not the best for sensitive skin I was very excited to receive a sample of this product free to test from Influenster, but was disappointed when I put it on it caused some redness and irritation in my cheek area. I’m not sure if it’s the fragrance which comes from lavender oil but is quite apparent. On the other areas of my face that aren’t as sensitive this product does a wonderful job of hydrating the skin so I can see it has potential but for sensitive skin I recommend getting a sample before diving in for a full size.
Date published: 2018-01-08
Rated 3 out of 5 by from Must be paired with correct cleanser I experience dry skin on my face and this product is advertised to correct dryness but I found that using this product the dryness did not go away when the foundation was applied because I botched dryness at the end of day all over my face.. however I realized that I have been using a face wash for persons with dry skin. After switching face washes the dryness decreased but I’m not sure using the cream really helped all that much. By itself this cream has the faint scent. It goes on smooth and I liked it was part of a theee step system. I received this product free for testing.
Date published: 2017-12-26
Rated 5 out of 5 by from Ultra moisturizing! I’m 25 years old, even tho my primary concern is not anti-aging, I’m aware that start using this kind of products is very beneficial for your skin! I have combination skin and huge pores. I could notice that using this moisturizer along with the new Hyaluronic Acid Intensifier, my pores looked smaller and a firmer looking skin speacially in the cheeks area. Beside that it’s ultra moisturizing and it feels nice now in the winter. Definitely I recommend it for elder women or young women who want to start an anti-aging routine. I received this product as a free sample for testing.
Date published: 2017-12-20
Rated 5 out of 5 by from Soothing I have used the same facial cream for about a year and have been pleased with it, but I have noticed my skin started adjusting to the continued use. I was happy when I was given a free sample of Triple Lipid Restore 2:4:2 in an Influenster VoxBox. When I first used it, I expirenced tingling and immediately felt a difference in my skin. It felt much smoother and hydrated with one use. After several uses, I could see a difference in the texture of my skin and the blemishes I had, began to clear up. I am convinced this is the cream I need to be using for the health of my skin.
Date published: 2017-12-07
Rated 5 out of 5 by from Great Product First off I would like to say that I love this product. I have pretty decent skin so really my purpose was to use this as a moisturizer. I have combination skin and most moisturizers make my skin extra oily looking after 2 hours. I don't mind a little glow but if I'm looking like a bucket of grease was poured on my face then its a problem. I have tried many products like this and when I say this is number 1, it's just that good. Honestly, when I saw the price for this cream I was shocked it was as expensive as it is but id say if you have the money to splurge then go for it.
Date published: 2018-02-01
Rated 5 out of 5 by from Evened my skin out! I received this product for free from influenster for testing purposes. I am typically skeptical of new skincare because I know what works for my extreme combination skin. This moisturizer really evened out my skin and delivered moisture where I needed it most without making my skin extra oily where it usually gets oily. I have dark spots and redness and I noticed that they aren’t as noticible after using this product. It is great under a variety of foundations, and I look forward to buying the full size when I run out!
Date published: 2018-01-15
Rated 5 out of 5 by from Great for sensitive skin! I am 39-years old and have dry, sensitive skin with Rosacea so I have to be careful with anti-aging products that may irritate my skin. This anti-aging cream is great for sensitive skin as it doesn’t irritate my skin at all. I received this product free for testing purposes and am honestly so impressed. Even though I've been using anti-aging products for quite some time, I never noticed any real anti-aging effects on my skin until now. Used in combination with the H.A. Intensifier, this cream improves the appearance of my skin, making it smoother, tighter and a little brighter! The cream is lightweight and provides the perfect amount of hydration. I’ve already run out of my sample and will be purchasing some more!
Date published: 2018-01-01
Rated 5 out of 5 by from Immediate Improvement I received this product as a free sample through Influenster. I quit my regular face routine and starting using a Skinceuticals routine a week ago. After the first night I noticed an improvement in the redness in my face. I feel like it’s helping to create a much better foundation for my makeup as well. I’ve received several compliments on my skin this week. This product goes on really smooth and the smell nice too. I’m anxious to see even more important in my skin in the next few weeks. I would definitely buy this product and I’d like to try more of the products.
Date published: 2017-12-02
Rated 3 out of 5 by from Ok but not amazing I love skinceuticals and I believe in the integrity and intention of their products. I have combination skin that has gotten significantly dryer as I get older. My biggest problem area is my forehead which alternates between dry and oily with some fine lines. When it comes to triple lipid restore cream I love the texture and the way it applies evenly to my skin and moisturizes throughout. It does an excellent job of evening out the moisture levels on my entire face. So all in all I really like it. The only problem I have is that the cream is good but not exceptional. In a very competitive industry I expect a product of this price to have a dramatic effect. The best results seem to only come from using this in tandem with another very expensive product. To me that is over the top and unnecesssary. There are many products out there with equal results and quality for a fraction of the price.
Date published: 2018-01-26
Rated 5 out of 5 by from Beautiful skin I am 52 an have dry skin. I don't have pimples but I had a couple of spots where I could feel tiny little bumps. I stared using this and noticed they completely disappeared. Its like it healed my skin and people do notice my skin and compliment me one it. on my second jar!
Date published: 2016-09-06
Rated 5 out of 5 by from Worth the $$$ This is an amazing product and just the right 'weight' for a moisturizer. This one is a keeper.
Date published: 2017-04-16
Rated 3 out of 5 by from Not that impressed I received this as a free sample to review and I didn’t see much of a difference. However my sample size was so small I only used it for about a week but I saw no difference. Felt like a normal moisturizer and is nice under make up as a base. I have oily skin so it’s hard for me to use any other moisturizers I can trust to keep my make up on. I’m sure if I had a larger sample I could get more use and see a difference. It’s a nice consistency and I enjoyed it but it wasn’t enough to make a difference in my skin in my opinion.
Date published: 2018-01-05
Rated 5 out of 5 by from Like silky butter! I received my free sample and I have to say it was so creamy and soft it almost felt like silk on my skin. It lasted longer then I thought for a free sample so I imagine the bottle I ordered will last me awhile. I am 40 and starting to notice wrinkle and stress lines this made my face feel soft and young again and just looked healthier after only a few uses. Also I have very sensitive skin and most products burn asp. on my face so i was please to not have a stinging sensation will be buying forever!
Date published: 2018-07-14
Rated 5 out of 5 by from Smooth Texture I have oily skin, but I get dry patches. My main concern is texture. I really enjoyed this cream. It absorbed so quickly, and did not leave my skin feeling oily. I was able to wear it under my makeup. I noticed a big difference in my pores shrinking and my texture was so much better. After applying my skin is plump and firmer. Other high moisture creams leave my skin feeling greasy, but not this one. Pro tip: a little goes a long way. You don't need to apply much
Date published: 2017-12-02
Rated 5 out of 5 by from I'm Glowing I have used a lot of products to achieve radiant glowing skin. Many of them have done nothing. This product absorbed so quickly and so well into my skin. I could tell that it was designed to be very effective. My skin is so dry in the winter and this product is a lifesaver. I can feel my skin getting more thin and fragile as I get older. In only one night my skin felt rejuvenated. I had a glow and my skin was more plump and moisturized. I have drier patches on my face, and this evened out my skin texture too! The best part is there is no oily or greasy feeling.
Date published: 2018-01-09
Rated 5 out of 5 by from Best face cream! I love this face cream, initially I tried the age interrupter, but did not like that one. So my esthetician recommended I try triple lipid restore. What a difference, this cream is so much more richer and creamer, my face feels so moisturized.
Date published: 2018-08-27
Rated 4 out of 5 by from Great Hydration! I received a sample of this from influenster for free so I could leave a thoughtful and honest review in exchange. Unfortunately, I wish my sample size had been larger. The sample lasted me about a week or two. I have relatively oily to normal skin. However recently, my skin has been dryer with the temperature change. After sampling triple lipid restore, my face and neck absolutely felt much more hydrated. Skin was smooth and My face immediately absorbed the product well without leaving any oily/overly creamy residue. I would love to purchase this item to further test it’s abilities to help with dryness or fine lines. The cost might be slightly over my preferred budget, but with so many incredible reviews, it’s hard to resist.
Date published: 2018-01-09
Rated 5 out of 5 by from My HG Moisturizer At this point I have lost count of how many different moisturizers I have tried for my oily/dehydrated skin. All moisturizers make me look like an oil slick within 1-2 hours, requiring blotting my entire face several times throughout the day. Some leave a sheen on my face I cant even blot off. I am dark skinned, so oil is much more noticeable on my skin and can make it look dull. Triple Lipid Restore has been such a surprising find. I expected it to be very heavy and oily. But its a great moisturizer that truly hydrates, plumps up fine lines, and seems to prevents TEWL. It absorbs well and leave a matte finish. My skin looks like it has an inner glow. I also think it has decreased/prevented oil overproduction. I have to blot my nose once mid day and that's it. I save it for the mornings or nights out because 1. its expensive and 2. it does not make my face oily. I don't care how I look going to bed. It also wears well under makeup. One recommendation/request I have to the brand would be for an airless pump packaging. Otherwise it is overall a great product.
Date published: 2018-12-14
Rated 5 out of 5 by from EXCELENT MOISTURIZER I received this cream complimentary from influenster for testing purposes in my Dermablend & skinceuticals voxbox and I am absolutely loving it, this is a very rich moisturizer perfect for dehydrated skin, or an excellent option for the winter time. Is very well absorbed, does not leave any greasy residue, and gives a very healthy looking glow. My skin is combination, but lately I've been noticing some dry patches around my cheeks, and they completely disappeared after start using this moisturizer. I am definitely buying the full size of this cream.
Date published: 2017-12-06
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