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Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 493.
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A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

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Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types

Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Once or twice daily, apply a small amount between fingertips, warm and melt the cream in circular motions. Apply twice daily to on face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before


    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof

  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

Physician image

I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen


Rated 5 out of 5 by from AMAZING!!! I love this product SO much! I have been using this for more than a year now and can tell a HUGE change in my skin. My skin is so much more smoother and softer. I love the way it smells too! Thank you for making such a wonderful product.
Date published: 2020-01-01
Rated 5 out of 5 by from Product that delivers results I have been using Triple Lipid Restore 2:4:2 for three weeks. My skin has improve already. Much smoother like a baby face and foundation looks better. Also, fine lines and wrinkles are reducing. It is not greasy and has a relaxing scent much like peppermint. Makes me want to apply it all over my body. Definitely we continue to use this product. I have been using SkinCeuicals Physical Fusion UV Defense for a year, recommended by my dermatologist due to sun damage. Next product will be C E Ferulic.
Date published: 2019-12-22
Rated 5 out of 5 by from Obsessed with this! I love this product! I use it at night as lotion and sometimes during the day under my regular sunscreen/moisturizer. My skin can be dry in the winter and this product always helps. A little goes a long way. I will only be using this from now on. Already on my second bottle.
Date published: 2019-12-18
Rated 5 out of 5 by from Great!!! Amazing!!! Every night and in 2 weeks you will see the difference
Date published: 2019-12-17
Rated 5 out of 5 by from 2nd bottle I have started my second bottle and love this cream. Very moisturizing without being greasy and my skin looks plump
Date published: 2019-11-25
Rated 5 out of 5 by from Happy I think this is one of my favorite creams ever! I have dry sensitive skin and this feels amazing. I can't wait to put it on in the evening. The texture, thickness, and smell. I am very sensitive ti smell. This just has a light refreshing clean smell and feel! Worth very penny.
Date published: 2019-11-18
Rated 5 out of 5 by from Amazing product Very pleased with this product. It was a recommendation from a friend. After a few days of use, my co-worker noticed a difference with my skin. I used it every day in the winter!
Date published: 2019-11-18
Rated 5 out of 5 by from Best moisturizer I have ever used. Wonderful moisturizer. Exactly what I’ve been looking for! Make my face feel nurtured, soft and well cared for.
Date published: 2019-10-10
Rated 1 out of 5 by from Very disappointed I will preface this review by saying that I have been using skin ceutical products since 2002. I love their antioxidents. I have been using the CE Feurlic and Hydrating B5 gel since 2002, and have recommended those products to friends. Several years ago, I switched products briefly and went to another line because the asthetician I was seeing suggested changing skin care lines from time to time. I came back to skin ceuticals within a month and have not changed since. After using the CE feurlic for so many years in my daytime regime, I recently purchased the Resveratrol BE for nighttime use. I needed a moisterizer to pair with this product. I had a sample of the AGE Interrupter and tried it with the BE. I did not get the hydration I needed from the AGE, so I bought the Triple Lipid Restore based, in part, on the reviews, and, in part, on the recommendation of a customer care representative. I really wanted to like this product, and was expecting to like it given the high cost and my experience with other skin ceutical products. However, I was very disappointed. It did not absorb into my skin, and I left it on all night. So I gave it ample time. When I woke up in the morning the cream felt sticky and thick on my face. It seemed like a cheap product that one would buy at a low end department store. It was not the same quality as the other skin ceutical products I have used. I have returned this product.
Date published: 2019-08-31
Rated 5 out of 5 by from A boon to my skin - love it! I recently added Triple Lipid Restore 2:4:2 to my skin care regimen - I have aging skin and needed a good moisturizer to go with C E Ferulic and Hyaluronic Acid Intensifier - and Triple Lipid Restore is so creamy and nourishing and feels so good, and doesn't dry my skin (A.G.E. Interrupter did not work well for me--too drying). I highly recommend it for drier, aging skin.
Date published: 2019-08-09
Rated 5 out of 5 by from LOVE LOVE LOVE Hands down the best SkinCeuticals product in my opinion! I've been using it for 2 years now and have had amazing results! My skin is oily but this evens out my skin tone/texture and gives me just enough moisture without over doing it.
Date published: 2019-07-24
Rated 5 out of 5 by from Beat face cream I’ve ever used! I’ve been using this face cream for 6 months but saw changes to my skin within the first month. It’s the only face cream that ever shrunk my pokes and keeps my skin tight
Date published: 2019-07-03
Rated 5 out of 5 by from Great Moisturizer with Results! I use this in the AM after my applying my CE Ferulic and before my sunscreen and again at night when I do not use the Glycolic 10 product. Perfect moisturizer. Keeps skin balanced and hydrated. Really improved overall hydration and skin condition. Worth the price!
Date published: 2019-07-03
Rated 5 out of 5 by from Great I am glad I bought this product, it works great. My skin tone more even now. It worth the price.
Date published: 2019-06-22
Rated 5 out of 5 by from It Works I first purchased the Triple Lipid Restore Cream 9 months ago. Totally pleased with the results, the surface texture of my skin has changed, so much smoother! The deeper lines have decreased. Plan to continue this product.
Date published: 2019-06-10
Rated 5 out of 5 by from My Holy Grail This is my third jar of this stuff and it is a must have in my day to day! I have very dry, mature skin and this is a lifesaver. Makes my skin feel amazing and keeps it plump and moisturized. It is pricey...but my skin loves this stuff and I can't live without it! Note*** It is absolutely wonderful after any kind of facial treatment, if your using a retinoid, or even derma rolling.
Date published: 2019-06-09
Rated 5 out of 5 by from Best Cream for Sensitive Skin I have extremely sensitive skin. I have been using another brand for more than 10 years, which is gentle but not enough for me any more when it comes to my 30s. Triple Lipid is my first Skin Ceuticals product. I talked to my specialist about the inflammation after treatment and she recommended this cream for my specific concern. It is very gentle that I can use it right after facial treatment. I can feel my skin is hydrated and at the same time the inflammation lasts short since I use this cream (Usually, it takes 4 days to recover, but it takes only one to two days for me now). Since it helped my inflammation, I started replacing it as my daily moisturizer. After about two weeks, I can totally tell my skin is getting stronger not just improvement in pore or smoothness. BUT, I don't get redness at the end of day. I don't have to worry itchy skin or rash after walking under the sun or in the garden as much any more. It does not only moist the skin when one applies it. It does improve the skin itself. Highly recommended!
Date published: 2019-06-09
Rated 5 out of 5 by from Highly recommend for daily skin maintenance I have been using 2:4:2 for 3-4 years now. I was first introduced to this product via a plastic surgeons office. It has worked wonders for me. It has assisted in preventing wrinkles and providing hydration to my skin. It is light and does not block pores.
Date published: 2019-06-09
Rated 5 out of 5 by from Great moisturizer! I’ve been using triple lipid restore for the past couple of years, and it is one of my ‘must haves’ In my skin care regimen. It relieves my dry skin due to aging, as well as relief from occasional sunburns. I highly recommend this product especially when using the retinol products. Along with the AGE eye cream, this product has greatly improved my fine lines.
Date published: 2019-06-09
Rated 2 out of 5 by from Not the best product for me I have been using this for about 2 weeks, since I run out of my other day mosturizer and decided to try this instead. It mosturizes just like my old one, yet does nothing better. So I am not thrilled to buy another jar once it is finished.
Date published: 2019-06-08
Rated 5 out of 5 by from Awesome I have dry skin; been using this product for two months and it has made such a difference for my skin. Will continue to use!
Date published: 2019-06-08
Rated 5 out of 5 by from Amazing hydration! I ran out of this product and used a clean beauty moisturizer for a month and my esthetician noticed immediately a diminished hydration. I returned to the fold and using again and within days fine lines and softness had returned! I am also using with the AHA Intensifier and it’s huge boost to my skin. Never going back!
Date published: 2019-06-08
Rated 5 out of 5 by from Loved! But went through quickly Loved this moisturizer! It was the only way my skin made it through the Colorado winter with the dry, dry air here. I was a little bummed at how quickly I went through the jar - hoped it would last longer.
Date published: 2019-06-08
Rated 5 out of 5 by from Great product! Since I sm using it, I have received the best compliments about how my skin looks!!!
Date published: 2019-06-08
Rated 5 out of 5 by from Amazing product Triple lipid restore is an amazing cream rhat works great and smells good. I noticed a difference in my skin within a few weeks. I just ordered my 3rd jar and I honestly can say that nothing works as as good.
Date published: 2019-06-08
Rated 5 out of 5 by from Triple lipid restore I love this product. It stays on my skin all night, and moisturizes the best I've had. Not oily or greasy.
Date published: 2019-06-08
Rated 5 out of 5 by from Huge improvement of skin. I bought this 3 years ago before my daughters wedding. Wanted to look my best on her day. Thought I would give it a try and go back to my old face cream after her special day. 3 years later and I am never going back. My skin color is much more even and smooth looking.
Date published: 2019-06-08
Rated 5 out of 5 by from Love! My skin feels so hydrated when I use this! I absolutely love it!
Date published: 2019-06-08
Rated 5 out of 5 by from Noticeable results I have been using this product for a few months and I love it. It has alleviated my dry skin and has a lovely subtle scent. I highly recommend.
Date published: 2019-06-08
Rated 5 out of 5 by from My skin is finally hydrated! I really love this product. My skin never feels tight and dry anymore.
Date published: 2019-06-08
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