Add to Favorites

Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 520.
  • y_2020, m_9, d_27, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_2, bvpage2n
  • co_hasreviews, tv_4, tr_516
  • loc_en_US, sid_3606000434967, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_skinceuticals-us
  • bvseo_sdk, dw_cartridge, 17.1.0, p_sdk_3.2.0
  • CLOUD, getAggregateRating, 69ms
  • reviews, product

A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

skin types


skin condition




In Stock

Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types

Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Apply a small amount between fingertips, warm and melt the cream in circular motions. Apply once or twice daily to face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before


    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof

  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

Physician image

I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen


Rated 5 out of 5 by from Awesome product I received a sample of this product and applied it to a tiny scar by my eye from a melanoma and it took the final line away from a tiny scar .i can't imagine what a full size product would achieve. Thank you!
Date published: 2020-08-17
Rated 5 out of 5 by from My skin looks smoother and softer! I bought this product after receiving a sample and it's definitely worth the price! The skin around my face, neck, and chest areas look smoother and softer. The scent also reminds me of a spa. I typically prefer unscented products but the scent is nice.
Date published: 2020-08-15
Rated 5 out of 5 by from Love this product I love everything about this product, especially how it makes my skin feel, and look. I've been using it along with the CE Ferulic serum for over a year, and cannot believe the change in my skin's texture and appearance. No fine lines, and dark spots are starting to diminish. Win win for me.
Date published: 2020-08-01
Rated 5 out of 5 by from Great Cream! I received a sample of this cream and instantly loved it. It feels luxurious to put on and my skin feels so smooth afterwards.
Date published: 2020-07-28
Rated 5 out of 5 by from Skinceuticals Triple Lipid Restore I received a free sample of Skinceuticals Triple Lipid Restore. I love how my skin felt soft and was moisturized from Skinceuticals Triple Lipid Restore. My skin looks smoother and younger from this wonderful product.
Date published: 2020-07-23
Rated 4 out of 5 by from Good product Have been using this around 1 month. It's very hydrating and my skin’s appearance looks good.
Date published: 2020-07-23
Rated 5 out of 5 by from It Really Works!!! I was looking for something with more than just a moisturizer. I love SkinCeuticals and bought the Triple Lipid Restore 2: 4 :6 . It's not like other moisturizers. I've already bought another jar of the Triple Lipid Restore 2:4:6 even thought I have more than 1/2 left. I don't want to run out of this cream with lipids, peptides, etc that makes my skin look more youthful.
Date published: 2020-07-22
Rated 5 out of 5 by from Wouldn’t want to do without I have been using Triple Lipid Restore for about a year. I believe it is keeping my skin, along with some other Skinceutical products, looking as good as possible.
Date published: 2020-07-06
Rated 4 out of 5 by from lightweight I tried a sample tube and I was able to use it twice. Overall it's light weight and creamy. Yet I don't feel and big difference in my skin. I like that it didn't cause ny skin irritation or redness. It seems to absorb well into the skin as well. It does leave a hydrating layer on your skin.
Date published: 2020-06-26
Rated 5 out of 5 by from Hydrating Have been using this for about 3 months. Very hydrating and has improved my skin’s appearance overall. I have really noticed a major improvement in the mouth & chin areas.
Date published: 2020-05-30
Rated 1 out of 5 by from creamy doesn't do anything at all for my skin, there was no difference in appearance
Date published: 2020-05-23
Rated 5 out of 5 by from Fabulous Skin Plumper Eliminates Aging Look Use one jar on a regular basis and then transition to a dupe, then you'll realize that the Triple Lipid Restore is an outstanding product.
Date published: 2020-05-21
Rated 5 out of 5 by from Best moisturizer for aging skin This cream is so thick and rich and luxurious . This is a splurge but definitely worth it. A little goes a long way . Not for combo or oily skin, this creamy moisturizer is for moisture depleted skin.
Date published: 2020-05-18
Rated 5 out of 5 by from Can't live without People always ask what I use on my skin and I recommend this product all the time. I have really sensitive skin and break out very easy. Because of the breakouts I have to use products that tend to dry out my skin. Not only does this keep my skin moisturized but it doesn't cause any breakouts. This cream improves the appearance of texture and fullness and because it is so gentle it is perfect for anyone who is concerned with aging skin.
Date published: 2020-05-02
Rated 5 out of 5 by from Smooth I finally tried this and I really like it! I use retin A 2-3 a week and on those days that my skin is sloughing off this is one of the only creams that works! It’s thick and a little on the heavy side but absorbs in and I notice a difference in the smoothness of my skin.
Date published: 2020-04-28
Rated 5 out of 5 by from Love it so much I would love to buy it a friend gave me some to try
Date published: 2020-04-20
Rated 5 out of 5 by from Best product ever I love this product. Every bit worth the money. Would not use anything else.
Date published: 2020-04-18
Rated 5 out of 5 by from Happy customer! I never bought anti aging creams and was overwhelmed when I started my research. I have eczema and sensitive skin, so I’m always leery about new products but I’m really happy with this purchase! Within a month, I already see a difference.... my wrinkles seem a little less and my skin feels very hydrated!
Date published: 2020-04-11
Rated 5 out of 5 by from Very rich and moisturizing I love this product. It's super rich and moisturizing! Helped get rid of my flaky skin.
Date published: 2020-04-10
Rated 5 out of 5 by from Great product! I am 42 years old and I have been taking care of my skin since I was 25. I have been using Skinceuticals for the last 6 years and I am extremely happy with their products. I only have fine lines on the outer corner of my eyes that shows when I smile and on my forehead that shows when I lift my eyebrows. Although there is no miracle product that will permanently erase those fine lines, this product definitely helps nourish my skin, making my skin look healthier and most importantly preventing those fines lines from becoming deep wrinkles. I use this product twice a day , it has a thick consistency , but it absorbs quickly. All my skin care products are from skinceuticals, they work really good together and I trust the science behind it.
Date published: 2020-02-24
Rated 5 out of 5 by from I love it I bought this item due to the love of Skinceuticals. I really liked the texture and weight of this moisturizer doesn't feel greasy, a little goes a long way and I will continue to use!
Date published: 2020-02-15
Rated 5 out of 5 by from Love everything about it! I am not a person who is impressed with “hype” and unfounded claims about a product and never write reviews because I am usually disappointed with most products. However, I thought I would splurge and give myself a gift and purchased this because my skin has become dry and wrinkly looking as I am an aging woman. I have used this cream everyday for about one month without any other skin care treatment on my face except my daily makeup and foundation. I can honestly say I have seen a decrease in fine lines and wrinkles especially under my eyes as it is also a wonderful eye cream. I love it’s scent which is fresh and clean and I look forward to putting it on my face everyday. It is not greasy and I use a lot because I just love it. My skin looks smoother and firmer and my pores are smaller which was a nice surprise. I do have some old acne scars on my face which it has not helped but I know it was not meant to. I will definitely be purchasing again!
Date published: 2020-02-10
Rated 5 out of 5 by from BEST PRODUCT FOR DRY SKIN This product was recommended to me by my esthetician when I was on Accutane. If you don’t know, accutane can make your skin severely dry and flaky to the point where no moisturizer was doing the do job. I would have chunks of skin falling off during work and then my skin would get red and irritated because I’d be trying to scrape it off to make it look better. This product along with the phyto corrective gel & masque worked wonders. It helped me tremendously while on accutane and afterwards. I continued to use this product years later. After one use on a dry patch, your skin will be glowing and moisturized like you’ve never seen before. I’m an esthetician and I use numerous product lines but Skin Ceuticals will always be my favorite.
Date published: 2020-01-31
Rated 5 out of 5 by from Great product I needed some more moisturizer and was t really impress .. I use the c-serum brightener and been very happy so after reading reviews I decided to try the lipid restore .. 2.5 weeks user and will continue w my skin regime .. highly recommend .. skin is silky , Dewey :) perfect .. 47 yrs young
Date published: 2020-01-19
Rated 5 out of 5 by from Best night cream ever! I received a sample of this cream and almost ended up giving it to my mom as after going over the ingredients, I thought it'd be more suited for her mature skin. However, I've heard good things about SkinCeuticals and decided to give it a try myself. I'm so glad I did! This cream was my introduction to the brand. I woke up and just kept looking at myself in a mirror because my skin looked so good. In fact, I thought how much younger I looked. A lot of creams leave my skin greasy in the morning, but not this one. My skin looked plump, it was soft, my pores seemed smaller and my number 11s were not as profound. I have combination skin and this cream did not make it greasy at all. Even when I apply it, my skin looks more matte. There was no irritation, no breakouts and it has a very pleasant herbal lavender scent which is in no way strong at all. So, those who are sensitive to smells, rest assure. I would even describe the scent as soothing and calming. Perhaps due to lavender. I then spent quite sometime educating myself about the brand and the products. Although I'm in my mid 30s, I didn't know that there were medical grade skincare and regular beauty stores skincare. Ever since trying SkinCeuticals, I stopped using whatever I've accumulated at skincare/makeup retailers at Malls and other places. With SkinCeuticals I noticed immediate results. After a few more uses, I realized that I could not live without this night cream. So, I bought a night cream and a serum. Fast forward a month later, most of my skincare now consists of SkinCeuticals. Why!?! Because I see results. My skin hasn't looked this good since I was in my 20s. I would rather have two products that work than a graveyard of cremes that don't. My. mom's birthday is coming up, and I will be getting her some SkinCeuticals products as well because they are simply amazing!
Date published: 2020-01-18
Rated 5 out of 5 by from From scaly to dewy skin I discovered this moisturizer and have been using it daily for 10 months (I have run out and am here to order more). I have AWFUL skin to start with: it is sensitive, I get bouts of cystic acne (I am 27), it's dry, and it looks transparent and discolored. The final straw was last winter when my cheeks got so dry that it became scaly and inflamed. I heard of this moisturizer via a makeup artist and decided to invest in it. BEST choice I've made. The scaliness and redness disappeared and my skin tone evened out to a more uniform color and appeared more plump. Best part is it doesn't irritate my acne in any way. Can't live without this product!
Date published: 2020-01-06
Rated 5 out of 5 by from Dewy skin again This, along with the Serum 10 AOX+, has made an incredible difference in my skin. My dry skin with fine wrinkles becomes smooth and dewy with a little bounce. I have very sensitive skin, and I have had no problems with either product. I first tried the Emollience cream and may try it again during the summer, but it was not enough for winter dry skin.
Date published: 2020-01-01
Rated 5 out of 5 by from AMAZING!!! I love this product SO much! I have been using this for more than a year now and can tell a HUGE change in my skin. My skin is so much more smoother and softer. I love the way it smells too! Thank you for making such a wonderful product.
Date published: 2020-01-01
Rated 5 out of 5 by from Product that delivers results I have been using Triple Lipid Restore 2:4:2 for three weeks. My skin has improve already. Much smoother like a baby face and foundation looks better. Also, fine lines and wrinkles are reducing. It is not greasy and has a relaxing scent much like peppermint. Makes me want to apply it all over my body. Definitely we continue to use this product. I have been using SkinCeuicals Physical Fusion UV Defense for a year, recommended by my dermatologist due to sun damage. Next product will be C E Ferulic.
Date published: 2019-12-22
Rated 5 out of 5 by from Obsessed with this! I love this product! I use it at night as lotion and sometimes during the day under my regular sunscreen/moisturizer. My skin can be dry in the winter and this product always helps. A little goes a long way. I will only be using this from now on. Already on my second bottle.
Date published: 2019-12-18
  • y_2020, m_9, d_27, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_2, bvpage2n
  • co_hasreviews, tv_4, tr_516
  • loc_en_US, sid_3606000434967, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_skinceuticals-us
  • bvseo_sdk, dw_cartridge, 17.1.0, p_sdk_3.2.0
  • CLOUD, getReviews, 21ms
  • reviews, product