Add to Favorites

Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 648.
  • y_2021, m_1, d_16, h_17
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_2, bvpage2n
  • co_hasreviews, tv_4, tr_644
  • loc_en_US, sid_3606000434967, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_skinceuticals-us
  • bvseo_sdk, dw_cartridge, 17.1.0, p_sdk_3.2.0
  • CLOUD, getAggregateRating, 70ms
  • reviews, product

A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

skin types


skin condition




In Stock

Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types

Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Apply a small amount between fingertips, warm and melt the cream in circular motions. Apply once or twice daily to face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before


    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof

  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

Physician image

I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen


Rated 5 out of 5 by from Smells Great! This product works great. It's not too heavy on the skin and it smells soothing. I have very sensitive skin and I did not break out to this at all. I also noticed my my skin more vibrant and fuller after three use.
Date published: 2021-01-06
Rated 5 out of 5 by from Fabulous I received my sample, and although it is a small amount to see a result of a single day, but I suffer from dryness in my forehead, cheeks and I leave the area of ​​my skin hydrated and soft, thanks for the sample.
Date published: 2021-01-05
Rated 5 out of 5 by from Great I love this !! It made my wrinkles disappear and faded out my scar
Date published: 2021-01-05
Rated 5 out of 5 by from Really works! I have only been using Triple Lipid Restore for a short time. The first time I used it, I could feel it working on my face like nothing I had tried before. It is correcting in every sense of the word. It feels good on, meaning its not greasy or to dry. There is no scent, which is great because I already have enough scent on me from my other products. The best part, results come quickly and your skin feels brand new!
Date published: 2021-01-04
Rated 2 out of 5 by from Not enough Did not receive enough of it to really judge. Need more.
Date published: 2021-01-04
Rated 3 out of 5 by from She’s thick Received this as a free trial sample. The packaging is simple but sleek. This has a nice subtle scent. The texture is thick and creamy which is lovely. I used this sparingly and enjoyed it. I have oily combination skin so if I used too much of this it made my skin oily. I’d definitely recommend to dry skin types.
Date published: 2021-01-01
Rated 5 out of 5 by from Seems awesome! I received a sample. I have only used it one time but my skin drank this stuff up! My skin is very dry on my cheek area. After applying, my skin felt moisturized and supple!
Date published: 2020-12-29
Rated 2 out of 5 by from I dunno I got the sample and saw immediate results but the full size shows no results at all. I often wonder if they water down the full sizes in many brands. I wish the cream were less heavy. I am seriously disappointed since it has a hefty price which i could agree to if only it worked as well as the sample.
Date published: 2020-12-28
Rated 5 out of 5 by from The best anti aging product I received a sample, and after using once a day for a week, till ran out. I couldn’t believe the softness, better looking pores and wrinkles just in a week once a day. Woukd definitely refer. I’m ordering my bigger bottle
Date published: 2020-12-28
Rated 5 out of 5 by from Best Moisturizer Ever I have loved the 2:4:2 since I tried the sample. I am in my early 50’s so my skin is starting to dry out...and it’s winter! My skin is definitely smoother, looks younger with the “plumper “ skin and is perfectly moisturized.
Date published: 2020-12-27
Rated 5 out of 5 by from A mini spa. My face said Thank You! Got this as a sample. My skin soaked it in and immediately felt so nourished and refreshed. It is perfect! A little goes a long way and your face will thank you. My skin felt so moisturized and healthy in the morning.
Date published: 2020-12-27
Rated 5 out of 5 by from Highly recommended So thankful for the sample that led me to the best product from such an amazing eco friendly brand
Date published: 2020-12-27
Rated 3 out of 5 by from Great texture Sample is only enough for a couple of applications so not enough time to see any results but I liked the way my skin felt after applying it. Soft and subtle
Date published: 2020-12-25
Rated 5 out of 5 by from Silky smooth... I've been a skincare fanatic for 30 years. This cream goes to the top of my list. It was so hydrating but not heavy. It's not greasy and melted into my skin. This cream feels so luxurious and I'll keep it in my routine. Thank you for helping me discover my new go-to moisturizer!
Date published: 2020-12-25
Rated 5 out of 5 by from it works I had gotten a small sample and it lasted me a week, (I use everything sparingly due to my skin type). It made my skin so soft, and it didn't smell bad (big plus for me). I love it, though the price is too high for me currently, due to the pandemic. Definitely worth it though.
Date published: 2020-12-22
Rated 5 out of 5 by from Great skincare product! I received my sample and with the first use, I noticed an improvement!
Date published: 2020-12-20
Rated 5 out of 5 by from MUST HAVE I received this as a sample with a previous order, and I am so glad I did! This cream is AMAZING! I use it twice a day in the morning after my CE Ferulic and H A intensifier and at night after my retinol... it’s so creamy smooth! It keeps my skin so hydrated, silky smooth and has a dewy glow! I will continue to purchase this cream!!!!
Date published: 2020-12-19
Rated 5 out of 5 by from Love It Soaks right into my skin and doesn't leave my face oily. Great product!
Date published: 2020-12-18
Rated 3 out of 5 by from Thick It's a nice sample size, it's a little too heavy for my skin. It didn't soak in, I could smell the chemicals as well. My face did feel softer, I just dont like the chemicals. But if you don't mind them and you need a heavier face cream then this may be for you.
Date published: 2020-12-18
Rated 5 out of 5 by from Best Ever I have never been able to wear a y type of moisturizer. Everything wreaked havoc on my skin. Triple Lipid went on smoothly ( a little goes a long way) and kept my skin refreshed throughout the day. I can put on makeup over it and it doesn’t bead up as some products do. It acts as a primer. Not too keen on the hefty price tag but I did buy the full size as I’ve searched for so long for something that works and it accommodates all of my skin’s needs.
Date published: 2020-12-18
Rated 5 out of 5 by from Just what i needed Recieved this a little while ago ! & i love it ! I seriously do. Its so much better than expected. & i have already bought more. You will not regret this purchase. You deserve it.
Date published: 2020-12-17
Rated 2 out of 5 by from Old lady smell I know that sounds mean but I never really knew what would make that "old lady smell", but wearing this made my husband tell me I smelled like a grandma! I am not one, nor am I close to being one. I received a little tiny bottle sample I was sent that barely covered my nose. It was so stinky and terrible smelling that all I can think of was "so this is what that old lady smell is caused from". I will never know if this actually truly works because the size of the sample bottle was a pinky length long of a kid. It was filled literally with almost nothing. I squeezed the entire tube till it was almost flat before the little bit of product came out. I was barely able to cover my nose, let alone a cheek. The face was out of the question. The customer service lady told me the only reason for sending out a sample is so you can smell the product and feel the texture . That's ridiculous for $128 product. The texture is the no different than any other moisturizer on the marke, and the smell, barf! Therefore I cannot justify spending $128 on a terrible terrible smelling product. I just wish they would make it smell like olay or scent free. Plus, give a better sample if you really want people to switch to your product.
Date published: 2020-12-17
Rated 5 out of 5 by from Love it! This product is awesome. I began using it and immediately my skin felt refreshed. In a week's time I began to notice fine lines lessening. I would greatly recommend it to everyone.
Date published: 2020-12-16
Rated 4 out of 5 by from feels great smells amazing i could feel and see such a huge difference in the texture and firmness in my skin almost immediately ! i will definitely be ordering a full size bottle in the near future.
Date published: 2020-12-13
Rated 4 out of 5 by from Fast absorption Fast absorption. Skin feels very smooth. Good product. Thanks
Date published: 2020-12-12
Rated 5 out of 5 by from Bomb face lotion I got a sample of this stuff &fell in love ! Its so hydrating &left my skin feeling so smooth &soft. I deffinately plan on buying a full size in the future!
Date published: 2020-12-10
Rated 5 out of 5 by from Small sample, BIG results Although it's a small sample, i only needed a small amount to moisturize my face. Not oily and very light. Love it
Date published: 2020-12-10
Rated 5 out of 5 by from Amazing hydration! I am so thankful for the sample I received! I will never use any other brand!! I love it!
Date published: 2020-12-08
Rated 5 out of 5 by from So smooth! I loved, loved, loved, this product. It made my skin so soft and smooth. I had the sample size and it left me yearning for more.
Date published: 2020-12-08
Rated 4 out of 5 by from Great product Tried this a month ago and was amazed at my skin it smells good and feels great leaving my skin radiant!
Date published: 2020-12-05
  • y_2021, m_1, d_16, h_17
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_2, bvpage2n
  • co_hasreviews, tv_4, tr_644
  • loc_en_US, sid_3606000434967, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_skinceuticals-us
  • bvseo_sdk, dw_cartridge, 17.1.0, p_sdk_3.2.0
  • CLOUD, getReviews, 8ms
  • reviews, product