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Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 493.
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A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

skin types

Dry
Normal
Oily
Combination
Sensitive

skin condition

Dehydrated
Aging

$128.00

Availability:

In Stock

Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types


Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Once or twice daily, apply a small amount between fingertips, warm and melt the cream in circular motions. Apply twice daily to on face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before
    after

    CLINICAL STUDY

    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof


  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

Physician image

I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen

Reviews

Rated 5 out of 5 by from Amazing I have been using this product for two years. I believe that recently they revamped the recipe. It works better than ever! I love being in my mid-30s and people always thinking I’m in my early 20s. Save so much money on fillers.
Date published: 2019-06-08
Rated 5 out of 5 by from The Best Moisturizer After treatment I had really dry skin. So my specialist put this product on my face and immediately I felt the difference. My face felt so hydrated therefore, I end up buying the cream right there and there. For a week I used it Day and night. My face looked radiant no matter how tired I was. My wrinkles are not as prominent, my skin feels so supple and smooth. I can’t live without it. I immediately told my specialist how much of a difference it had made on my skin. I am so glad she introduced this to me. I always buy the most expensive skin care but none of it does what this cream can do. It’s light, it’s motivating to see my skin glow once again. Awesome! Awesome! Product. Last note: I have melasma and my melasma have improved, the darkness has gotten lighter and my skin improved overall.
Date published: 2019-05-15
Rated 5 out of 5 by from Excellent Results I wish they would bring back my all time favorite, the Skin Firming Cream. In the meantime, this product an excellent alternative. The results are worth the expense.
Date published: 2019-05-06
Rated 5 out of 5 by from Moisture This product is great for dry skin and it is the only product I need at night, even in the winter!
Date published: 2019-04-29
Rated 5 out of 5 by from Fountain of Youth I have been using this cream for 7 months now and it is my favorite item of all my skin care products. The transformation has been awesome which I never thought was possible. My skin is full and more youthful looking since using this. Love it!
Date published: 2019-04-26
Rated 5 out of 5 by from Wonderful moisture! I have used this for several years and I love how moisturized my is now.
Date published: 2019-04-26
Rated 5 out of 5 by from Best cream ever! I’ve been using this morning and evening for over a year and love it! Love the way my skin looks.
Date published: 2019-04-25
Rated 5 out of 5 by from Light weight and great! I’ve been using this pricey product for several years on my face & neck. It is light weight & goes on evenly. I swear my skin craves this stuff! My skin is tighter and my wrinkles are less defined.
Date published: 2019-04-24
Rated 5 out of 5 by from Excellent moisturizer! Hands-down the best facial moisturizer I have ever used. I’ve been using this for over a year now and have no intentions of changing
Date published: 2019-04-23
Rated 4 out of 5 by from Very hydrating The best face lotion I have used. I wish it wasn’t so expensive.
Date published: 2019-04-22
Rated 5 out of 5 by from Amazing I have been using Triple Lipid Restore for 2 months and my skin has never looked better. The product is thick and covers quite a bit of surface area, but does not feel heavy. Once applied, my skin has a dewy look that lasts for hours. I use this in combination with CE Ferulic and will not look back.
Date published: 2019-04-22
Rated 4 out of 5 by from A treat for my face! I purchased this a few weeks ago along with a number of Skinceuticals products. I'm not sure which product, or if the combination of products, gave me results, but I have seen results in a short amount of time. My face was uncomfortably dry and tight. Since using this product, my skin feels healthy and looks dewy. When I use this at night, I wake up and my skin is still incredibly hydrated. I also have extremely sensitive skin and will get rashes and hives to certain ingredients, but have had no reaction to Skinceuticals products! The Triple Lipid has a soft, milky texture but not too thick. It smells wonderful too and has me feel like I'm getting a full spa treatment. The only downside is if you put this on and follow it up 5 min or even 30 min later with the overnight dry cream, the product pills into annoying white balls that are hard to get off so I have to wash and feel like I'm wasting the expensive product. Skinceuticals responded and I guess they should not be used together so I've stopped.
Date published: 2019-04-22
Rated 5 out of 5 by from Like a day at the SPA I bought this on the recommendation of the woman who does my facials and I must say it is even better than she described . It feels like a spa quality product that leaves you with that post facial glow. Will be a staple going forward for me
Date published: 2019-04-22
Rated 5 out of 5 by from Great Product My skin is sensitive and can be dry. This product feels great and I have seen improvement with my skin.
Date published: 2019-04-21
Rated 5 out of 5 by from Love it I love this product . I love how it makes my face feel. I will not use anything but this on my face. I tell everyone how good it is.
Date published: 2019-04-21
Rated 5 out of 5 by from Amazing progress! At first, I didn’t notice much change in my skin. However, the progress soon became extremely apparent. My skin eventually glowed and looked way more youthful! All of my friends have complimented my skin tone and have asked what I use. I strongly recommend this product!
Date published: 2019-04-21
Rated 5 out of 5 by from Love this moisturizer I use this product every morning and absolutely love it. It is very moisturizing and leaves my skin feeling smooth and soft. I recommend this product to all of my friends as a must have when trying out the Skinceuticals skin care line. Remarkable visibly differences when using this product. I can’t go without it.
Date published: 2019-04-21
Rated 5 out of 5 by from Marvelous I have added this to my skin ceutical “love” list. I can feel a real difference in my skin.
Date published: 2019-04-21
Rated 5 out of 5 by from Texture is perfect This cream goes on with a overall feeling of moisture without the greasy feeling. My skin feels hydrated and I love how smooth my skin feels the next day. You only need a dab so it will last a good long while.
Date published: 2019-04-21
Rated 5 out of 5 by from Amazing Product I have been using Triple Lipid Restore for a year and a half now. It’s amazing! I have super sensitive skin and it doesn’t irritate it. I have turned several of my friends on to this product! You will not be disappointed!
Date published: 2019-04-21
Rated 5 out of 5 by from Luxurious moisturizer I love Triple Lipid Restore! I use it whenever my skin feels dehydrated, particularly in the cooler months. I love to use CE Ferulic then Hylaronic and on top this moisturizer during the day. This combination helps my skin look refreshed and dewy. I’m in my upper 40’s and many people think I’m 10 years younger.
Date published: 2019-04-20
Rated 5 out of 5 by from Highly effective Highly effective, rich cream, comparable with creme de la mer in its results.
Date published: 2019-04-20
Rated 5 out of 5 by from Triple Lipid Restore- WOW I had very dry skin on my forehead that was flaking no matter what I used, and putting on make up was more of a nightmare because of it. Nothing helped. I tried many moisturizers. My dermatologist gave me a sample of this and it worked amazingly. Instant relief and continuous improvement as I used it. I bought it, I love it, so worth it. Highly recommend !
Date published: 2019-04-20
Rated 5 out of 5 by from Restoring is good product Nice product, feels good on skin. Definitely recommend
Date published: 2019-04-20
Rated 5 out of 5 by from Skin feel soft I have been using this product for about 3 months and I have seen a difference with my skin glowing and the even skin tones.
Date published: 2019-04-20
Rated 5 out of 5 by from Game Changer I have very dry skin and this product has been a life saver. Expensive, but worth it.
Date published: 2019-04-20
Rated 5 out of 5 by from Great product I have been using this product for over a year now. I love how my skin feels in the morning.
Date published: 2019-04-20
Rated 5 out of 5 by from Best moisturizer ever I’ve used this product for two years now. I’ve tried a couple other moisturizers since initially buying this product simply because the price is pretty steep for me, but I haven’t found a moisturizer that even comes close to how effectively this product works. It leaves my skin looking so smooth and glowing! I have very acne-prone skin, and this product along with Skinceuticals Retinol has tremendously improved the appearance of my skin. HOLY GRAIL OF MOISTURIZERS!!!
Date published: 2019-04-20
Rated 5 out of 5 by from Love this product!! As I have gotten older my skin has become drier & more sensitive. My Skinceuticals estitician first used 2-4-2 on my skin. I HAVE NOT TRIED ANYTHING ELSE SINCE!! My skin loves 2-4-2! My skin looks healthy, smooth & clear. Would highly recommend Triple Lipid 2-4-2!!
Date published: 2019-04-20
Rated 5 out of 5 by from Short & sweet My skin just sucks this up , between my ce Ferulic , my HA & this it is the perfect combo for me , I get so many compliments on my skin , I wear NO FACE MAKEUP & am 50 ,, thank you skinceuticals !
Date published: 2019-04-20
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