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Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 504.
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A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

skin types

Dry
Normal
Oily
Combination
Sensitive

skin condition

Dehydrated
Aging

$128.00

Availability:

In Stock

Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types


Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Apply a small amount between fingertips, warm and melt the cream in circular motions. Apply once or twice daily to face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before
    after

    CLINICAL STUDY

    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof


  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

Physician image

I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen

Reviews

Rated 5 out of 5 by from Amazing Product I have been using Triple Lipid Restore for a year and a half now. It’s amazing! I have super sensitive skin and it doesn’t irritate it. I have turned several of my friends on to this product! You will not be disappointed!
Date published: 2019-04-21
Rated 5 out of 5 by from Luxurious moisturizer I love Triple Lipid Restore! I use it whenever my skin feels dehydrated, particularly in the cooler months. I love to use CE Ferulic then Hylaronic and on top this moisturizer during the day. This combination helps my skin look refreshed and dewy. I’m in my upper 40’s and many people think I’m 10 years younger.
Date published: 2019-04-20
Rated 5 out of 5 by from Highly effective Highly effective, rich cream, comparable with creme de la mer in its results.
Date published: 2019-04-20
Rated 5 out of 5 by from Triple Lipid Restore- WOW I had very dry skin on my forehead that was flaking no matter what I used, and putting on make up was more of a nightmare because of it. Nothing helped. I tried many moisturizers. My dermatologist gave me a sample of this and it worked amazingly. Instant relief and continuous improvement as I used it. I bought it, I love it, so worth it. Highly recommend !
Date published: 2019-04-20
Rated 5 out of 5 by from Restoring is good product Nice product, feels good on skin. Definitely recommend
Date published: 2019-04-20
Rated 5 out of 5 by from Skin feel soft I have been using this product for about 3 months and I have seen a difference with my skin glowing and the even skin tones.
Date published: 2019-04-20
Rated 5 out of 5 by from Game Changer I have very dry skin and this product has been a life saver. Expensive, but worth it.
Date published: 2019-04-20
Rated 5 out of 5 by from Great product I have been using this product for over a year now. I love how my skin feels in the morning.
Date published: 2019-04-20
Rated 5 out of 5 by from Best moisturizer ever I’ve used this product for two years now. I’ve tried a couple other moisturizers since initially buying this product simply because the price is pretty steep for me, but I haven’t found a moisturizer that even comes close to how effectively this product works. It leaves my skin looking so smooth and glowing! I have very acne-prone skin, and this product along with Skinceuticals Retinol has tremendously improved the appearance of my skin. HOLY GRAIL OF MOISTURIZERS!!!
Date published: 2019-04-20
Rated 5 out of 5 by from Love this product!! As I have gotten older my skin has become drier & more sensitive. My Skinceuticals estitician first used 2-4-2 on my skin. I HAVE NOT TRIED ANYTHING ELSE SINCE!! My skin loves 2-4-2! My skin looks healthy, smooth & clear. Would highly recommend Triple Lipid 2-4-2!!
Date published: 2019-04-20
Rated 5 out of 5 by from Short & sweet My skin just sucks this up , between my ce Ferulic , my HA & this it is the perfect combo for me , I get so many compliments on my skin , I wear NO FACE MAKEUP & am 50 ,, thank you skinceuticals !
Date published: 2019-04-20
Rated 5 out of 5 by from Moisturizing I’ve been using this product for about 3 years and love it. I have dry skin and it keeps me nourished all day. I use it as a day cream and night cream. It’s thick and feels great.
Date published: 2019-04-20
Rated 5 out of 5 by from Light and luxurious There is a reason why this moisturizer is constantly out of stock. It is amazing!
Date published: 2019-04-20
Rated 5 out of 5 by from The one! This is my one and only treatment cream that I use. My skin feels supple, moisturized, and so smooth. Some might think it's on the heavier side, but I love waking up and still lightly feeling the cream on my face. I have sensitive skin that breaks out easily to many products, but I have zero problems with this cream.
Date published: 2019-04-20
Rated 5 out of 5 by from Best night cream ever! I have been using Skinceuticals for about two months now and I am amazed with results! I wish I found it sooner. The cream is rich enough for my sensitive combination skin and helps with the fine lines. I would totally recommend it!
Date published: 2019-04-20
Rated 5 out of 5 by from Perfect for dry skin. I have been using this moisturizer for 3 years. I had extremely dry skin and this product was the solution.
Date published: 2019-04-20
Rated 5 out of 5 by from Light as a feather I’ve been using this product for several years. I use it in the morning, after I put on a few drops of the H.A. Intensifier. Triple lipid restore 2:4:2 reduces redness. It would be perfect if it also had sunscreen.
Date published: 2019-04-20
Rated 5 out of 5 by from My Favorite cream I’ve been using this cream for over a year now and I can tell you it has made my skin so smooth and clear. I have seen my fine lines disappear and applying My foundation is easy. I will never stop using Triple Lipid Restore
Date published: 2019-04-20
Rated 5 out of 5 by from Love it saved my skin in the winter I got this and it literally saved my skin in the winter and helped so much when using retinol.
Date published: 2019-04-19
Rated 5 out of 5 by from Smoothness I truly believe this product has made my face smoother than ever. Dewy glow that I can see and feel.
Date published: 2019-04-19
Rated 5 out of 5 by from skin saver I had laser resurfacing done in Nov. I had a lot of drying throughout the winter and this is the face cream/lotion that saved me. It is luscious. I intend to replenish again, however, it is almost May, (7 months later), and I still have plenty! Worth it.
Date published: 2019-04-19
Rated 5 out of 5 by from The best! I’ve been using the CE Ferulic for years as recommended by my dermatologist so tried this cream this year and I totally love it. High quality, light and rich feeling at the same time. My skin is super dry and it works. Highly recommend!!
Date published: 2019-04-19
Rated 5 out of 5 by from Love Triple lipid restore I have used this product for over four years and I finally found a product that makes me look and feel younger. My skin feels so good in the morning. It works too
Date published: 2019-04-19
Rated 5 out of 5 by from The BEST product I’ve been using this product for about six months. The BEST moisturizer. I use it at night and it feels so silky and clean - not oily. Within minutes it is absorbed into my skin and in the morning, still feels so soft. It makes my skin look younger and healthy! I do not get any breakout at all like other products. If you are looking for a great moisturizer that really works as it says it will - - BUY THIS PRODUCT.
Date published: 2019-04-19
Rated 5 out of 5 by from Amazing! I love this stuff. I use it every night before bed. It makes my skin so soft and helps with my aging. Pricey but worth it and lasts about 3-4 months. I love the smell of it too!
Date published: 2019-04-19
Rated 5 out of 5 by from Love it! I’ve been using it for over a year and every time I put it on my face I can’t believe how good it feels and smells!
Date published: 2019-04-19
Rated 5 out of 5 by from Best Moisturizer I’ve ever Used Although this skin cream is very expensive, it’s worth it. After a couple of months of using it, my skin feels soft, looks rosy, and the fine lines around my mouth are much less visible. In addition, my neck looks dramatically smoother. Highly recommended!
Date published: 2019-03-16
Rated 5 out of 5 by from excellent moisturizer I use it at night. Soaks in well, is non greasy, but really moisturizes well, even under eyes.
Date published: 2019-03-15
Rated 5 out of 5 by from Helps so much! I got this item a few weeks ago and used it on my really bad dry skin. About two weeks later, (I used it every day) my skin couldn't feel better. I would definitely tell others to buy it. It is even a lower price for a really amazing item like this!
Date published: 2019-02-12
Rated 5 out of 5 by from My HG Moisturizer At this point I have lost count of how many different moisturizers I have tried for my oily/dehydrated skin. All moisturizers make me look like an oil slick within 1-2 hours, requiring blotting my entire face several times throughout the day. Some leave a sheen on my face I cant even blot off. I am dark skinned, so oil is much more noticeable on my skin and can make it look dull. Triple Lipid Restore has been such a surprising find. I expected it to be very heavy and oily. But its a great moisturizer that truly hydrates, plumps up fine lines, and seems to prevents TEWL. It absorbs well and leave a matte finish. My skin looks like it has an inner glow. I also think it has decreased/prevented oil overproduction. I have to blot my nose once mid day and that's it. I save it for the mornings or nights out because 1. its expensive and 2. it does not make my face oily. I don't care how I look going to bed. It also wears well under makeup. One recommendation/request I have to the brand would be for an airless pump packaging. Otherwise it is overall a great product.
Date published: 2018-12-14
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