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Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 679.
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A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

skin types

Dry
Normal
Oily
Combination
Sensitive

skin condition

Dehydrated
Aging

$128.00

Availability:

In Stock

Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types


Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Apply a small amount between fingertips, warm and melt the cream in circular motions. Apply once or twice daily to face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before
    after

    CLINICAL STUDY

    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof


  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

Physician image

I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen

Reviews

Rated 5 out of 5 by from Great I got a sample tube and noticed how it removed wrinkles in a few days. I love this product but being a widow on a very limited income I cannot afford to buy it. Thank you for the opportunity to try it.
Date published: 2021-03-06
Rated 4 out of 5 by from Works great, would prefer no essential oils I tried the sample and can already tell this is a superior and well developed product after just a few uses. Lots of brands with more hype and less payoff for the money to not compare to this product. Good job Skinceuticals! I just dont like the tingly feeling of the peppermint oil. Maybe you have EO free version? Here’s hoping :-)
Date published: 2021-03-02
Rated 4 out of 5 by from Nice consistency! Got a sample and love how well it goes on and doesn't have any excessive oilyness or anything as an after effect! Didn't get to use long enough to attest to helping with wrinkles but definitely recommend trying!
Date published: 2021-03-02
Rated 3 out of 5 by from Sample review I recently received a sample of this cream. I wish the sample was bigger so I had more time to try it, but after seeing the price of this product, I understand why it was so small. It only lasted a few days and I honestly don’t think it was enough time to see any results. I will say though that it felt great on my skin and my skin was so soft and smooth after application. It felt light and was non-greasy, which I loved. I just wish I had more of it, or a promo code included to purchase the full jar would have been great. I would recommend based off what I experienced with the sample as far as how it made my face feel after applying.
Date published: 2021-02-28
Rated 5 out of 5 by from Feels amazing I received this as a free sample to try and review and I absolutely love it. I plan on purchasing the full-size soon and I highly recommend it for anybody looking to anti-age their skin. My skin feels soft and plumps out my fine lines and it makes me feel beautiful
Date published: 2021-02-27
Rated 3 out of 5 by from Not moisturize as I expect That cream as not moisturize as I expected and I don't like the smell. It smells like chemicals.
Date published: 2021-02-26
Rated 5 out of 5 by from Love it!! I added this cream to my skin care routine about a month ago and all I can say is WOW!! My skin looks great on Zoom! Zoom video calls made me realize my skin looks so dull and tired, one month of this product and my skin is glowing!!
Date published: 2021-02-24
Rated 4 out of 5 by from Nice Night Cream I received a sample. I used it at night. Although the cream is thicken feel, it goes smoothly on my face, keeps my face nourishing all night in the winter time.
Date published: 2021-02-22
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