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A.G.E. Interrupter Wrinkle cream

A.G.E. Interrupter is rated 4.7 out of 5 by 27.
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High-concentration anti-wrinkle cream formulated to improve the visible signs of aging caused by advanced glycation end-products (A.G.E.)

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Product Details

A.G.E. Interrupter is an advanced wrinkle treatment that fights the visible signs of aging caused by advanced glycation end-products (A.G.E.), a major factor of the natural aging process. This anti-aging cream is formulated with an unprecedented 30% concentration of proxylane™, 4% blueberry extract, and 0.2% phytosphingosine (pronounced fi'to-sfing'go-sen) to improve the appearance of wrinkling and restore the loss of firmness caused by the glycation process.

  • Reduces the appearance of skin creping and thinning
  • Visibly improves the appearance of fine lines, wrinkles, and skin texture
  • Restores water and nutrients to improve the look of skin firmness
  • Comforts dry, aging skin
  • Alcohol-, and dye-free

How To Use


Once or twice daily, massage a thin, even layer onto the entire face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • visible results

    In a 12-week study, A.G.E. Interrupter showed a significant improvement in the appearance of wrinkles, firmness, and skin texture

    See Protocol

    A 12-week controlled clinical study on 41 subjects, ages 45-61. Subjects applied A.G.E. Interrupter twice daily.

  • Science & Proof

  • Science

    Intrinsic or natural aging, caused by internal factors such as hormonal shifts and changes in skin metabolism, contribute to the appearance of wrinkles, loss of firmness, and crepy skin.

    Glycation, a major factor of intrinsic aging, occurs when excess sugar molecules bind to collagen and elastin fibers and prompt the formation of advanced glycation end-products (A.G.E.). As a result, glycated collagen and elastin fibers lose the ability to function normally, and the body cannot break them down and replace them, leading to severe wrinkling of the skin.

    A.G.E. Interrupter is a uniquely-textured formulation optimized to help improve the visible signs of aging associated with glycation. This potent anti-wrinkle cream features a high-concentration combination of proxylane, blueberry extract, and phytosphingosine to improve visible signs of aging such as wrinkles, loss of firmness, and a crepy, thinning appearance.

Key Ingredients

  • 4% Blueberry extract
  • 30% Proxylane™
  • 0.2% Phytosphingosine

Naturally derived and both an antioxidant and anti-glycation ingredient helps fortify skin’s matrix and prevent the appearance of wrinkles and laxity.

Learn more about Blueberry extract

See all ingredients

aqua / water / eau, propylene glycol, dimethicone, hydroxypropyl tetrahydropyrantriol, cyclohexasiloxane, isohexadecane, glycerin, synthetic wax, dimethicone/peg-10/15 crosspolymer, aluminum starch octenylsuccinate, ci 77163 / bismuth oxychloride, phenoxyethanol, magnesium sulfate, ethylhexyl hydroxystearate, salicyloyl phytosphingosine, acrylates copolymer, methylparaben, ethylparaben, disodium edta, vaccinium myrtillus extract / vaccinium myrtillus fruit extract, parfum / fragrance, butylphenyl methylpropional, coumarin

Complete Your Regimen


Rated 5 out of 5 by from Fountain of Youth in a jar!! This product is awesome!!! I went to a day spa a couple of years ago for a facial and Skinceuticals was recommended for me. The A.G.E. Interruptor is phenomenal!!!nI have combination skin and wasn't sure this would be for me as it is for mature skin but it is fabulous. It is rich and creamy without being heavy. My skin loves it and you will too. I use the whole Skinceuticals regimen and constantly get compliments on my skin. I am turning 50 in a couple of days and people can't believe it. My skin looks years younger. It is pricey but so concentrated. You use so little of it that is lasts a long time. BUY IT!!! You will be so glad you did.
Date published: 2018-04-15
Rated 5 out of 5 by from Best Product I Have Ever Used This has got to be the best product I have ever used. I've spent hundreds of dollars on other products that just didn't show any results even after several months of use. A.G.E. Interrupter Works PERIOD. It took about 6 weeks of use for me to notice a difference and what a difference it has made. The lines on my forehead and the dreaded '11' frown lines have been so diminished. The best part is that A.G.E. Interrupter doesn't cause me to breakout like most creams do.nnnnThe texture of the cream is so luxurious and my skin feels nourished but not overly sticky. Yes the price is high but it truly is worth every penny. I'll be buying this again and again.
Date published: 2013-12-04
Rated 1 out of 5 by from Conflicted I bought this a few months ago and it was arguably the best cream that I have ever used. I reordered the product a little over a month ago and was surprised at the results when I started using it again. The thickness of the product is one of the reasons why I was so pleased with it in the first place; however, this time the cream does not rub in well and leaves a film-like residue on my skin, which is especially noticeable if I try to apply makeup over it. I previously wrote an inquiry regarding this product, but never received a response from the company. In fact, I have never received any response from them on the two separate occasions that I have written to them. Maybe since I am writing a review, they will finally care to get back to me.
Date published: 2017-09-18
Rated 5 out of 5 by from AWESOME PRODUCT!!! LOVE THIS!! I use this cream as my 'third step' after CE Ferulic and Hydrating B5 Gel...and finish off with Physical Fusion SPF 50 (4th Step)...Makeup application is a breeze ( I use an airbrush system with a primer) I usually get 12-15 hours of perfection with no makeup reapplication needed..My skin always looks amazing!! I found that all of the products work best when used in conjunction with one another..For reference, I visit my Esthetician every 3 weeks for derma-plane, light peel etc..I do 2 heavy peels yearly combined with laser as needed..
Date published: 2016-01-20
Rated 4 out of 5 by from Holds Moisture In! I found the value in this product when I ran out of it. It keeps the moisture in the skin, which in turn, helps to prevent the visual signs of aging. When I was running out and went to another dermatologist recommended product, my skin became very dry and irritated. I then applied last of what I had and it soothed the skin by the next morning. I will say it is a little heavy. I did develop some bumps in my cheek areas. But as soon as I instituted exfoliation on a daily basis, it went away. Overall I would recommend for those who want to treat more advanced signs of aging.
Date published: 2016-01-01
Rated 5 out of 5 by from Excellent Product I am so happy to have found this product. It is the best moisturizer I have ever used. It really does banish the crepiness that comes with age. My pores shrunk and the texture of my skin is beautiful. I was so impressed with this product, I ordered the CE Ferulic and B5 Gel, and they only made this product work better. Am planning to purchase an eye product, when I figure out which one would be best for me. Your products are outstanding.
Date published: 2010-10-29
Rated 5 out of 5 by from My search is over! I have tried every cream there is looking for one that would make a difference in my skin and also not cause sensitivities. This is hands down the best face cream out there. I have sensitive combination skin. I have occasional hormonal breakouts but still am concerned about fine lines and wrinkles. I have used for three days and I am amazed already at the results. my skin is glowing. please skinceuticals never ever discontinue this product. I should also mention I use and love the serums as well.
Date published: 2016-03-23
Rated 5 out of 5 by from Excellent! I've tried everything and nothing showed any difference in my skin. When I started using Skin Ceuticals, for the first time I noticed a dramatic difference. I even tried L_ Me_ and there was no change. I am a lifer with Skin Ceuticals. My skin is smooth and the skin tone is even and it stays that way unless I use something else. I use C.E. Ferulic with A.G.E. Interrupter at night and the moisterizing serum with the skin tightening lotion during the day. I will never change.
Date published: 2011-08-13
  • y_2018, m_9, d_25, h_19
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  • co_hasreviews, tv_0, tr_27
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  • clientName_skinceuticals-us
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