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A.G.E. Interrupter Wrinkle cream

A.G.E. Interrupter is rated 4.7 out of 5 by 63.
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High-concentration anti-wrinkle cream formulated to improve the visible signs of aging caused by advanced glycation end-products (A.G.E.)

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Product Details

A.G.E. Interrupter is an advanced wrinkle treatment that fights the visible signs of aging caused by advanced glycation end-products (A.G.E.), a major factor of the natural aging process. This anti-aging cream is formulated with an unprecedented 30% concentration of proxylane™, 4% blueberry extract, and 0.2% phytosphingosine (pronounced fi'to-sfing'go-sen) to improve the appearance of wrinkling and restore the loss of firmness caused by the glycation process.

  • Reduces the appearance of skin creping and thinning
  • Visibly improves the appearance of fine lines, wrinkles, and skin texture
  • Restores water and nutrients to improve the look of skin firmness
  • Comforts dry, aging skin
  • Alcohol-, and dye-free

How To Use


Once or twice daily, massage a thin, even layer onto the entire face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • visible results

    In a 12-week study, A.G.E. Interrupter showed a significant improvement in the appearance of wrinkles, firmness, and skin texture

    See Protocol

    A 12-week controlled clinical study on 41 subjects, ages 45-61. Subjects applied A.G.E. Interrupter twice daily.

  • Science & Proof

  • Science

    Intrinsic or natural aging, caused by internal factors such as hormonal shifts and changes in skin metabolism, contribute to the appearance of wrinkles, loss of firmness, and crepy skin.

    Glycation, a major factor of intrinsic aging, occurs when excess sugar molecules bind to collagen and elastin fibers and prompt the formation of advanced glycation end-products (A.G.E.). As a result, glycated collagen and elastin fibers lose the ability to function normally, and the body cannot break them down and replace them, leading to severe wrinkling of the skin.

    A.G.E. Interrupter is a uniquely-textured formulation optimized to help improve the visible signs of aging associated with glycation. This potent anti-wrinkle cream features a high-concentration combination of proxylane, blueberry extract, and phytosphingosine to improve visible signs of aging such as wrinkles, loss of firmness, and a crepy, thinning appearance.

Key Ingredients

  • 4% Blueberry extract
  • 30% Proxylane™
  • 0.2% Phytosphingosine

Naturally derived and both an antioxidant and anti-glycation ingredient helps fortify skin’s matrix and prevent the appearance of wrinkles and laxity.

Learn more about Blueberry extract

See all ingredients

aqua / water / eau, propylene glycol, dimethicone, hydroxypropyl tetrahydropyrantriol, cyclohexasiloxane, isohexadecane, glycerin, synthetic wax, dimethicone/peg-10/15 crosspolymer, aluminum starch octenylsuccinate, ci 77163 / bismuth oxychloride, phenoxyethanol, magnesium sulfate, ethylhexyl hydroxystearate, salicyloyl phytosphingosine, acrylates copolymer, methylparaben, ethylparaben, disodium edta, vaccinium myrtillus extract / vaccinium myrtillus fruit extract, parfum / fragrance, butylphenyl methylpropional, coumarin

Physician Insight

Physician image

A.G.E Interrupter is an impressive corrective cream that significantly improves the appearance of the visible signs of aging such as fine lines and wrinkles that are common as we age. It is an ideal for various skin types, and is a popular product requested by Park Avenue Medical Spa patients.

Dr. Anca Tchelebi-Moscatello - Park Avenue Medical Spa

Learn about Dr. Tchelebi-Moscatello

Complete Your Regimen


Rated 5 out of 5 by from Fountain of Youth in a jar!! This product is awesome!!! I went to a day spa a couple of years ago for a facial and Skinceuticals was recommended for me. The A.G.E. Interruptor is phenomenal!!!nI have combination skin and wasn't sure this would be for me as it is for mature skin but it is fabulous. It is rich and creamy without being heavy. My skin loves it and you will too. I use the whole Skinceuticals regimen and constantly get compliments on my skin. I am turning 50 in a couple of days and people can't believe it. My skin looks years younger. It is pricey but so concentrated. You use so little of it that is lasts a long time. BUY IT!!! You will be so glad you did.
Date published: 2018-04-15
Rated 5 out of 5 by from Best Product I Have Ever Used This has got to be the best product I have ever used. I've spent hundreds of dollars on other products that just didn't show any results even after several months of use. A.G.E. Interrupter Works PERIOD. It took about 6 weeks of use for me to notice a difference and what a difference it has made. The lines on my forehead and the dreaded '11' frown lines have been so diminished. The best part is that A.G.E. Interrupter doesn't cause me to breakout like most creams do.nnnnThe texture of the cream is so luxurious and my skin feels nourished but not overly sticky. Yes the price is high but it truly is worth every penny. I'll be buying this again and again.
Date published: 2013-12-04
Rated 5 out of 5 by from I recently noticed fine lines beginning to form on my forehead and was thinking Botox would have to be my next step. Soon after, my sister bought me the A.G.E. Interrupter cream along with the C E Ferulic daytime serum and the Resveratrol B E nighttime serum. I used these 3 products religiously and after a month I could see a HUGE difference! My forehead lines had faded and my skin felt hydrated and renewed. I eventually ran out of the cream and the fine lines did not immediately come back! This told me that the product was actually working on my skin and was not just a short term fix. I don't think I will ever try another moisturizer again.
Date published: 2019-02-26
Rated 1 out of 5 by from Conflicted I bought this a few months ago and it was arguably the best cream that I have ever used. I reordered the product a little over a month ago and was surprised at the results when I started using it again. The thickness of the product is one of the reasons why I was so pleased with it in the first place; however, this time the cream does not rub in well and leaves a film-like residue on my skin, which is especially noticeable if I try to apply makeup over it. I previously wrote an inquiry regarding this product, but never received a response from the company. In fact, I have never received any response from them on the two separate occasions that I have written to them. Maybe since I am writing a review, they will finally care to get back to me.
Date published: 2017-09-18
Rated 5 out of 5 by from This is the magic Potion!!!!! I went to my local beauty supply salon and I told the girls i needed something more for my aging skin..I am 54. They looked at me and suggested A.G.E. Interrupter. So i got some....This stuff is the magic potion, magic ,magic,magic!!!!!! i have used to many other things in the past,but this wonderful corrector is a miracle!!!! i cannot tell tell what it has done for me!!! i used it at night for the first time and I am predeposed to wind burn and skin dryness due to my aging process and weather changes here in Vermont. I had dry patches and I used this product and the next morning they were gone and replaced with smooth evenly toned skin. i suggest you get this!!! it is truly wonderful. I am buying it for my sisters for Christmas. it will be their favorite gift for sure!!!!!!!
Date published: 2010-11-20
Rated 5 out of 5 by from AWESOME PRODUCT!!! LOVE THIS!! I use this cream as my 'third step' after CE Ferulic and Hydrating B5 Gel...and finish off with Physical Fusion SPF 50 (4th Step)...Makeup application is a breeze ( I use an airbrush system with a primer) I usually get 12-15 hours of perfection with no makeup reapplication needed..My skin always looks amazing!! I found that all of the products work best when used in conjunction with one another..For reference, I visit my Esthetician every 3 weeks for derma-plane, light peel etc..I do 2 heavy peels yearly combined with laser as needed..
Date published: 2016-01-20
Rated 5 out of 5 by from The magic bullet After trying a zillion skin care products, I can say this is it for me. My skin has never looked better and more supple. I've been using it for 9 months along with the corresponding eye cream, and the bitty signs of aging I had are gone (I'm 40). Often people scoff when they learn my age or check my ID, not believing I'm 40. The price may be steep, but this jar has lasted me the 9 months I've been using it daily. I'm just close to running out, so I'll be reordering very soon. A little goes a long way, and it's worth every penny. The little lines I had on my forehead and under my eyes are completely gone, it's like magic. If you layer the Hydrating B5 Gel under it, your skin will feel and look like the finest silk. My search for a skin product that actually works is over!
Date published: 2018-05-29
Rated 5 out of 5 by from Best Wrinkle Cream On the Market This is the one product that keeps me coming back to SkinCeuticals. I have added other SkinCeutical products to my regimen, but this is the key. And when I'm in a hurry, this is the one I never skip and I carry a sample in my purse. I see visible results immediately as it smooths the wrinkles on my cheeks, around my mouth, on my forehead and even on my neck. I'm 67 and I've tried other wrinkle creams but nothing is as effective as this one in making my skin look smoother and younger.
Date published: 2018-12-07
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