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A.G.E. Interrupter Wrinkle cream

A.G.E. Interrupter is rated 4.5 out of 5 by 66.
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High-concentration anti-wrinkle cream formulated to improve the visible signs of aging caused by advanced glycation end-products (A.G.E.)

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In Stock

Product Details

A.G.E. Interrupter is an advanced wrinkle treatment that fights the visible signs of aging caused by advanced glycation end-products (A.G.E.), a major factor of the natural aging process. This anti-aging cream is formulated with an unprecedented 30% concentration of proxylane™, 4% blueberry extract, and 0.2% phytosphingosine (pronounced fi'to-sfing'go-sen) to improve the appearance of wrinkling and restore the loss of firmness caused by the glycation process.

  • Reduces the appearance of skin creping and thinning
  • Visibly improves the appearance of fine lines, wrinkles, and skin texture
  • Restores water and nutrients to improve the look of skin firmness
  • Comforts dry, aging skin
  • Alcohol-, and dye-free

How To Use


Once or twice daily, massage a thin, even layer onto the entire face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • visible results

    In a 12-week study, A.G.E. Interrupter showed a significant improvement in the appearance of wrinkles, firmness, and skin texture

    See Protocol

    A 12-week controlled clinical study on 41 subjects, ages 45-61. Subjects applied A.G.E. Interrupter twice daily.

  • Science & Proof

  • Science

    Intrinsic or natural aging, caused by internal factors such as hormonal shifts and changes in skin metabolism, contribute to the appearance of wrinkles, loss of firmness, and crepy skin.

    Glycation, a major factor of intrinsic aging, occurs when excess sugar molecules bind to collagen and elastin fibers and prompt the formation of advanced glycation end-products (A.G.E.). As a result, glycated collagen and elastin fibers lose the ability to function normally, and the body cannot break them down and replace them, leading to severe wrinkling of the skin.

    A.G.E. Interrupter is a uniquely-textured formulation optimized to help improve the visible signs of aging associated with glycation. This potent anti-wrinkle cream features a high-concentration combination of proxylane, blueberry extract, and phytosphingosine to improve visible signs of aging such as wrinkles, loss of firmness, and a crepy, thinning appearance.

Key Ingredients

  • 4% Blueberry extract
  • 30% Proxylane™
  • 0.2% Phytosphingosine

Naturally derived and both an antioxidant and anti-glycation ingredient helps fortify skin’s matrix and prevent the appearance of wrinkles and laxity.

Learn more about Blueberry extract

See all ingredients

aqua / water / eau, propylene glycol, dimethicone, hydroxypropyl tetrahydropyrantriol, cyclohexasiloxane, isohexadecane, glycerin, synthetic wax, dimethicone/peg-10/15 crosspolymer, aluminum starch octenylsuccinate, ci 77163 / bismuth oxychloride, phenoxyethanol, magnesium sulfate, ethylhexyl hydroxystearate, salicyloyl phytosphingosine, acrylates copolymer, methylparaben, ethylparaben, disodium edta, vaccinium myrtillus extract / vaccinium myrtillus fruit extract, parfum / fragrance, butylphenyl methylpropional, coumarin

Physician Insight

Physician image

A.G.E Interrupter is an impressive corrective cream that significantly improves the appearance of the visible signs of aging such as fine lines and wrinkles that are common as we age. It is an ideal for various skin types, and is a popular product requested by Park Avenue Medical Spa patients.

Dr. Anca Tchelebi-Moscatello - Park Avenue Medical Spa

Learn about Dr. Tchelebi-Moscatello

Complete Your Regimen


Rated 2 out of 5 by from Overpriced I do not understand why the price is so expensive. I have not noticed improvement in my skin and I'm on my second jar. I can no longer justify the price.
Date published: 2020-03-22
Rated 3 out of 5 by from Parabens? I love SkinCeuticals products. Recently i have been trying to learn more about what is actually in them. i was disappointed to find out that two of the products that I love contain parabens, is this associated with it being an anti-aging product? I am not sure why its highlighted in so many products that they don't contain parabens but then the Age interupter cream has parabens? Also wondering about propylene glycol as another added ingredient as I've heard its been shown to weaken protein and cellular structure of the skin.
Date published: 2020-02-27
Rated 1 out of 5 by from changed formula? This A.G.E. cream is different than the last time I got it. It is white and has a whipped, greasy texture. I'm 49. I could see and feel the effects of the last cream in one day. THIS cream does not absorb into my skin. I've been using it for two weeks, and it does NOTHING for my skin. I hope the formula hasn't changed, and this some kind of fluke with the distribution. I contacted the company and didn't receive a response. By writing a review maybe it will respond to my complaint.
Date published: 2020-02-25
Rated 4 out of 5 by from AGE it feels wonderful on my face. I’ve received several samples of this and I love it. I’m sure the Ingredients would show results. I haven’t purchased it because personally it is too expensive. I just can’t bring myself to pay that much for a face cream. I save for procedures that I like to get often instead. Can’t give five stars because of the price.
Date published: 2020-01-20
Rated 5 out of 5 by from Love this product!!!! I have purchased thousands of dollars for skin care over the past 10 years. THIS! I love this cream. My face feels so refreshed after using and I absolutely love it. I believe it is worth every penny!
Date published: 2020-01-19
Rated 2 out of 5 by from Disappointed Iv used it for a week No results a way over priced product that leave my skin needed additional moisturizer.. will give it Another week if no results sending this product back
Date published: 2019-12-29
Rated 1 out of 5 by from Fresh smell It did nothing more than over the counter products I have tried. I have used other Skin products from this company that did a good job but not this one. When you apply makeup over it the makeup gets cakey and doesn't look good.
Date published: 2019-10-22
Rated 5 out of 5 by from My skin loves this stuff!!! I am so glad this was reccomend to me after a hydrafacial. My skin went from oily to dry and flaky the past couple of years. The years of sun exposure certainly have made numerous line appearances especially on my forehead and eye areas. The first time I used it my skin soaked this in. It's a thick cream and perhaps I went a bit crazy with it at first and if you oversupply you will have some residue left. ( the only thing I dont like). After a few weeks of continuous use I started to see a difference. My skin is hydrated and firmer and it is no longer red and flaky. I look refreshed and I will never be without this product. The only thing I would suggest to Skinceuticals is to maybe add sunscreen. I use the Ultimate UV Defense SPF 30 which I love but I wouldn't mind having it all in one jar.
Date published: 2019-09-09
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