NEW BREAKTHROUGH

A.G.E. Interrupter Advanced

Anti-wrinkle cream

Breakthrough corrective cream helps reverse visible signs of aging impacted by glycation and collage ... Read full description

NEW

SkinCeuticals

A.G.E. Interrupter Advanced

Anti-wrinkle cream

48 ml
Old price New price $185.00

or 4 installments of $46.25 by

Learn more

⭐ Top Auto-Replenished Product

Quantity

EXCLUSIVE OFFER

Complimentary deluxe sample of Sheer Physical UV Defense on all orders.
Enter Code: PROTECT

Breakthrough corrective cream helps reverse visible signs of aging impacted by glycation and collagen decline, including fine lines and deep wrinkles.

SKIN TYPES: Dry, Normal, Combination, Sensitive

SKIN CONCERN: Aging

FEATURES:
Backed by 15+ years of glycation research and expertise, A.G.E. Interrupter Advanced is a potent anti-wrinkle cream that helps correct and defend against visible signs of aging. Formulated with 18% concentrated Proxylane^TM, 4.25% wild fruit flavonoid blend of blueberry and pomegranate extracts, and 0.1% glycyrrhetinic acid, this breakthrough corrective cream is clinically proven to smooth visible lines and deep wrinkles in five facial zones targeted for aesthetic procedures.

BENEFITS:

Helps address the complete multi-phase glycation process known to visibly age skin
Visibly smooths fine lines and five wrinkle types, including forehead wrinkles, nasolabial folds, marionette wrinkles, glabellar wrinkles, and crow’s feet
Delivers 24-hour hydration in a rich, satin texture
Comforts dry, aging skin
Free of parabens, drying alcohol, and dyes

TSA Approved Airplane icon

TSA Approved

Twice daily, massage a thin, even layer of A.G.E. Interrupter Advanced anti-wrinkle cream onto the entire face, neck, and chest.

If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a sunscreen.

If using with a retinol at night, apply after retinol application.

Learn how to incorporate this product into a comprehensive regimen >

18% CONCENTRATED PROXYLANE^TM
Helps support skin’s integrity and correct visible signs of aging, like wrinkles and laxity.
4.25% WILD FRUIT FLAVONOIDS
Blend of blueberry and pomegranate extracts helps defend against glycation, including UV-induced glycation, and protect against free radical damage.
0.1% GLYCYRRHETINIC ACID
Helps enhance skin’s natural radiance, countering dull and sallow tone linked to A.G.E. accumulation.
3% HEPES
Activates natural enzymes in the skin to promote even cell turnover while maintaining the skin’s moisture levels.
1% NIACINAMIDE
Water-soluble vitamin, also known as vitamin B3, soothes and helps support skin’s moisture barrier.

See All Ingredients

Aqua / Water, Hydroxypropyl Tetrahydropyrantriol, Glycerin, Propylene Glycol, Stearic Acid, Butyrospermum Parkii Butter / Shea Butter, Hydroxyethylpiperazine Ethane Sulfonic Acid, Palmitic Acid, Pentylene Glycol, Oleyl Alcohol, Arachidyl Alcohol, Myristyl Myristate, Panthenol, Niacinamide, Dimethicone, Isononyl Isononanoate, Bis-peg/ppg-16/16 Peg/ppg-16/16 Dimethicone, Glyceryl Stearate, Candelilla Cera / Candelilla Wax, Behenyl Alcohol, Peg-100 Stearate, Sodium Polyacrylate, Pentaerythrityl Tetraisostearate, 4-t-butylcyclohexanol, Arachidyl Glucoside, Caprylyl Glycol, Xanthan Gum, Chlorphenesin, Myristic Acid, Caprylic/capric Triglyceride, Glycyrrhetinic Acid, Parfum / Fragrance, Sorbitol, Vaccinium Myrtillus Fruit Extract, Potassium Hydroxide, Adenosine, Citric Acid, Punica Granatum Fruit Extract, Limonene, Coumarin, Linalool, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate

Collagen and elastin are responsible for skin’s youthful look. While many factors contribute to signs of aging in the skin, glycation of these structural proteins plays a significant role.

Glycation is a natural, multi-phase process that occurs when excess sugar molecules bind to proteins, including collagen and elastin, and form damaging byproducts known as advanced glycation end-products (A.G.E.s). External aggressors – such as UV, pollution, and diet – accelerate the glycation process, transforming collagen and elastin into A.G.E.s.

A.G.E.s turn flexible proteins rigid and brittle, making newly glycated collagen lose its critical regenerative ability. Once formed, these damaged proteins cannot be repaired or replaced, which ultimately weakens skin integrity and results in visible signs of aging including wrinkles, crepiness, sagging, and dullness.

A.G.E. Interrupter Advanced is a potent corrective cream designed to help reverse accelerated signs of aging impacted by glycation and collagen decline. Formulated with a high-concentration combination of Proxylane^TM, wild fruit flavonoids, and glycyrrhetinic acid, this breakthrough anti-wrinkle cream helps correct visible skin aging and defend against new and recurring damage. All in a luxuriously textured formula.

After 12 weeks, A.G.E. Interrupter Advanced improved attributes associated with skin aging and glycation, including lines and deep wrinkles in five facial zones.

-14% global fine lines
-11.5% forehead wrinkles
-11% nasolabial folds
-7% marionette wrinkles
-7% glabellar wrinkles
-7% crow’s feet

See Protocol

Protocol: A 12-week, single-center, clinical study was conducted on 77 females with Fitzpatrick type I-VI, ages 35-75, and mild to moderate global wrinkles, fine lines, laxity, rough skin texture, uneven skin tone, and a dull complexion. A.G.E. Interrupter Advanced was used twice daily over face, neck, and chest in conjunction with a sunscreen for 12 weeks. Efficacy and tolerance evaluations were conducted at baseline, weeks 4, 8, and 12.

Introducing New A.G.E Interrupter Advanced

NEED ADVICE? Take our Regimen Finder Quiz, designed with physicians Try Now | Connect with a Licensed Aesthetician (Mon – Sat: 11am to 9pm EST)

Take our Regimen Finder Quiz, designed with physicians Try Now

PHYSICIAN INSIGHT

A.G.E Interrupter Advanced is a breakthrough in anti-aging skincare because it addresses the complete glycation process, a natural and unavoidable factor of aging that affects all of our skin. I recommend to all my patients looking for at-home skincare to help reverse visible aging and am excited to pair with skin-tightening treatments like radiofrequency microneedling.

Dr. Sherry Ingraham, Advanced Dermatology

CLINICALLY PROVEN RESULTS

A.G.E. Interrupter Advanced Before and After

14%
Reduction in the appearance of global fine lines

11.5%
Reduction in the appearance of forehead wrinkles

7%
Reduction in the appearance of crow’s feet

See Protocol

GLYCATION EXPLAINED

WHAT IS GLYCATION?
AND HOW DOES IT AGE YOUR SKIN?

Glycation is a naturally occurring, biological process in which excess sugars bind to the structural proteins responsible for keeping skin supple and radiant, and form damaging byproducts known as advanced glycation end-products (A.G.E.s).

A.G.E.s cause these proteins, including collagen and elastin, to become weak and brittle, degrading their reparative ability and accelerating visible signs of aging.

3 SIGNS GLYCATION IS AGING YOUR SKIN

Wrinkles + crepiness
Loss of firmness
Dull + sallow tone

KEY INGREDIENTS

PRO FORMULA

Frequently Asked Questions

Answers to Your Frequently Asked A.G.E. Interrupter Advanced Questions

Similar to its predecessor, A.G.E. Interrupter Advanced is an anti-wrinkle cream specifically formulated to target the visible effects of glycation on the skin. Backed by 15+ years of glycation research and expertise, this next-generation technology now addresses all phases of the glycation process, including UV-induced glycation, helping to correct existing signs of skin aging and defend against new and reoccurring damage. Now formulated with an increased concentration of Proxylane^TM (+20% higher activity than A.G.E. Interrupter) and wild fruit flavonoids (+12.5% higher activity than A.G.E. Interrupter), as well as new glycyrrhetinic acid, A.G.E. Interrupter Advanced is clinically proven to smooth visible lines and wrinkles in five facial zones targeted for aesthetic procedures.

A.G.E. Interrupter Advanced features a combination of wild fruit flavonoids (blueberry and pomegranate extracts) that deliver 12.5% higher activity than the single flavonoid (blueberry extract) used in the original A.G.E. Interrupter formulation. Together, these naturally derived ingredients can contribute to a slightly pink tone; while this color may vary, the effectiveness of the formula remains constant.

A.G.E. Interrupter Advanced and Triple Lipid Restore 2:4:2 are complementary corrective creams that offer unique anti-aging benefits.

A.G.E. Interrupter Advanced helps address fine lines, wrinkles, and skin crepiness and thinning by helping reverse the natural glycation process known to accelerate visible aging. Formulated with a whipped, creamy-balm texture, this potent product may be used alone or in conjunction with other corrective treatments and moisturizers.

Triple Lipid Restore 2:4:2 helps address the loss of facial fullness, rough skin texture, and dullness by helping refill essential skin lipids and restore the skin barrier. Its silky, ultra-rich texture provides an intensely nourishing layer to lock in your skincare.

A.G.E. Interrupter Advanced and Triple Lipid Restore 2:4:2 may be used alone, alternated between morning and nighttime, or even layered together in your corrective skincare regimen to achieve optimal and comprehensive anti-aging results.

If layering both products, it is recommended to first apply a thin layer of A.G.E. Interrupter Advanced, then follow with Triple Lipid Restore 2:4:2.

Glycation, a major factor of intrinsic and extrinsic aging, occurs when excess sugar molecules bind to collagen and elastin fibers and prompt the formation of advanced glycation end-products (A.G.E.). Glycated collagen and elastin fibers lose the ability to function normally and cannot be broken down, repaired, or replaced, which ultimately leads to severe wrinkling of the skin.