Dr. Pinnell's Research
Dr. Pinnell’s Duke Antioxidant patent has been a driving force at SkinCeuticals since the company’s inception, but he has made other milestone discoveries along the way. His skin science research findings have been published in peer-reviewed journals and have since been universally accepted in the dermatological community.
Dr. Pinnell had 100 peer-reviewed publications, including many related directly to the topical antioxidant innovative technologies:
Topical L-Ascorbic Acid Percutanous Absorption Studies
Pinnell, S.R., et al.,Topical L-Ascorbic Acid: Percutaneous Absorption Studies.
Dermatol Surg 27:2, 137-142, 2001
SkinCeuticals was the first to discover the exact formulation specifications a topical antioxidant must meet in order to be effective on the skin. These parameters have become the gold standard for antioxidant formulation.
UV Photoprotection by Combination Topical Antioxidants Vitamin C and E.
Lin, J.Y., Selim, M.A., Shea, C.R., Grichnik, J. M., Omar, M.M., Monterio-Riviere, N.A., and Pinnell, S.R. J Amer Acad Dermatol 48: 866-74, 2003.
SkinCeuticals second-generation product marks an important milestone in the development of antioxidant technology. For the first time, it was possible to mix successfully an aqueous antioxidant (Vitamin C) with an oily antioxidant (Vitamin E).
Photodamage and Oxidative Stress and Protection Provided by Topical Antioxidants
Pinnell, S.R, J Am Acad Dermatol. 48(1): 1-19, 2003.
In order to provide full-spectrum protection against environmentally caused skin damage, it is imperative to use a topical antioxidant daily. This added protection from free radicals has been proven to help prevent the appearance of premature skin aging.
A Topical Antioxidant Solution Containing Vitamins C and E Stabilized by Ferulic Acid Provides Protection for Human Skin Against Damage Caused by Ultraviolet Irradiation.
Pinnell, S. et al. J Am Acad Dermatol. 59(3):418-25, 2008.
With SkinCeuticals third-generation topical antioxidant, C E Ferulic, it is possible to provide the skin with eight times its natural protection, as well as unprecedented anti-aging benefits.
Additional peer-reviewed publications prove the ineffectiveness of other antioxidants – including alpha lipoic acid, ubiquinone, idebenone, and kinetin – in protecting skin from oxidative stress:
Alpha Lipoic Acid is Ineffective as a Topical Antioxidant for Photoprotection of Skin.
Lin, J.Y., Lin, F-H., Burch, J.A., Selim, M. Angelica, Monterio-Riviere, N.A., Grichnik, J. M. and Pinnell, S.R. J Invest Dermatol, 123:5, 996-998, 2004.
Ubiquinone, Idebenone, and Kinetin Provide Ineffective Photoprotection to Skin When Compared to a Topical Antioxidant Combination of Vitamins C And E with Ferulic Acid.
Tournas, J.A., Lin, F-H, Burch, J.A., Selim, M.A., Monteiro-Riviere, N.A., Zielinski, J.E., and Pinnell, S.R. J Invest Dermatol, 126, 1185-1187, 2006.