Featuring: Dr. Julie Woodward, Oculofacial Plastic Surgeon, Duke University & Cori Ramos — SkinCeuticals Pro & Licensed Aesthetician
Hello everyone and welcome to Pro Live. Today we are introducing SkinCeuticals' newest innovation — A.G.E. Interrupter Ultra Serum. This is a formula developed to help visibly tighten and lift sagging skin across four key areas of the face: the forehead, cheeks, jawline, and neck.
A.G.E. Interrupter Ultra Serum works by addressing collagen decline in the skin. Collagen decline can happen from the natural aging process, environmental factors, sun damage, and rapid weight loss — all of which impact collagen integrity. This is a multi-corrective serum that has been tested in all skin types and skin tones, and physician-tested on GLP-1 patients. It is designed to be used alone in a morning and evening skincare routine, and can also complement in-office skin-tightening aesthetic treatments.
The ingredients in this double-patented formula are separated into two key technologies. First, Flavo-Proxylane technology — combining a high percentage of Proxylane with wild fruit flavonoids. These ingredients work together to support skin integrity and collagen, and help reduce oxidative stress. Second, the lifting boosters — Rhamnose and Gentiana Lutea extract — which work together to visibly firm, tighten, and sculpt the skin, boosting elasticity and firmness.
After 12 weeks, clinical testing shows that A.G.E. Interrupter Ultra Serum delivers up to 18% visible lift across the forehead, cheeks, jawline, and neck. It also reduces the appearance of wrinkles by up to 16% and increases smoothness by up to 54%.
I am joined today by Dr. Julie Woodward, an oculofacial plastic surgeon practicing at Duke University in Durham, North Carolina — the university where SkinCeuticals was invented and where all the original research was created. Dr. Woodward was personally and professionally acquainted with Dr. Sheldon Pinnell, the founding scientist of SkinCeuticals.
Dr. Woodward, why is A.G.E. Interrupter Ultra Serum exciting to you?
The research is very trending and new — it adds to the existing research on antioxidants in a new way. We all love CE Ferulic, Phloretin CF, and Silymarin CF as classic antioxidants, but this addresses anti-aging differently. Loss of elasticity really ages the skin and can affect people regardless of age. Different factors contribute to collagen decline. The name A.G.E. Interrupter refers to Advanced Glycation End Products — AGEs. These form when sugars combine with proteins and fats in the body, either from foods like the crust on toast or pizza, or created internally. AGEs break down collagen in the skin, accelerating visible aging.
Who would benefit most from A.G.E. Interrupter Ultra Serum?
All patients are candidates, but GLP-1 patients in particular benefit significantly. GLP-1 patients often experience rapid weight loss, which reduces skin nutrition. When a lot of fat is lost quickly, it changes the hormonal activity delivered to the dermis — fat stores estrogen, which supplies the skin with hormonal signaling. This product has been proven in GLP-1 patients to improve bounce, thickness, turgor, and lift in the skin. You do not need to be on a GLP-1 medication to benefit — it helps whether collagen decline is from rapid weight loss, normal aging, or dietary inflammation.
How do you use A.G.E. Interrupter Ultra Serum in a daily routine?
Morning: cleanse, apply your antioxidant serum — CE Ferulic for drier skin, Phloretin CF for hyperpigmented skin, or Silymarin CF for acne-prone skin — then A.G.E. Interrupter Ultra Serum, then sunscreen. Evening: apply retinol first on clean skin, then A.G.E. Interrupter Ultra Serum as your moisturizer. For those with rosacea or sensitive skin who cannot tolerate retinol, Phyto Corrective Gel is a calming alternative that can be used in its place. When layering multiple serums, the rule of thumb is thinnest to thickest in terms of consistency.
How does A.G.E. Interrupter Ultra Serum compare to H.A. Intensifier Multi-Glycan?
A.G.E. Interrupter Ultra Serum focuses on lifting and tightening sagging skin and loss of elasticity. H.A. Intensifier Multi-Glycan addresses loss of facial fullness, volume, and dehydration by stimulating glycans like hyaluronic acid — clinically tested to amplify hyaluronic acid content by up to 30%. They address two different concerns and complement each other beautifully. To layer: apply A.G.E. Interrupter Ultra Serum first, then H.A. Intensifier Multi-Glycan.
How does A.G.E. Interrupter Ultra Serum compare to A.G.E. Interrupter Advanced?
Both feature anti-glycation benefits and address collagen decline. A.G.E. Interrupter Ultra Serum targets sagging skin and loss of elasticity. A.G.E. Interrupter Advanced targets fine lines and deep wrinkles. One is a lightweight, layerable serum; the other is a rich whipped balmy cream moisturizer. They complement each other — apply A.G.E. Interrupter Ultra Serum first, then A.G.E. Interrupter Advanced.
Can A.G.E. Interrupter Ultra Serum be used with retinol?
Yes. Retinol goes on first, then A.G.E. Interrupter Ultra Serum after.
How does A.G.E. Interrupter Ultra Serum complement in-office treatments?
It was tested alongside in-office ultrasound lifting treatments. After an ultrasound tightening procedure — which involves minimal discomfort and no bruising downtime — A.G.E. Interrupter Ultra Serum can be applied directly. The patient then takes it home to continue using twice daily. In-office treatments and at-home skincare work together like the gym and a healthy diet — each is good on its own, but together they are unstoppable.
Dr. Woodward's SkinCeuticals desert island picks: CE Ferulic as her number one — because it prevents free radical damage, helps prevent sunburn, and delivers anti-aging correction. Sunscreen as number two. Retinol as number three — though she notes retinol is not her first choice on a desert island due to sun sensitivity.
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