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Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 489.
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A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

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Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types

Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Once or twice daily, apply a small amount between fingertips, warm and melt the cream in circular motions. Apply twice daily to on face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before


    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof

  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

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I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen


Rated 4 out of 5 by from Perfect For Elasticity & Healthy Glow I received this product as a free sample for testing. I only received the sample size version and loved it, so I had to order a brand new full-size jar! Compared to other anti-aging creams, I think it's fairly on the lighter side (which I like) and although it does still have that viscosity which I find very important in anti-aging products, my skin absorbed the product really quickly. I apply the cream at night after layering my night creams for extra restoration! Another pro tip is that I leave my jar in a mini skin care fridge that I have so it stays cool. I realize that applying "cool" products on my skin helps with firmness and elasticity!
Date published: 2018-01-10
Rated 5 out of 5 by from Hydrating and nourishing I received this product in exchange for a review. All opinions are my own. I'll admit I didn't want to like this because of the price point, but I can't stress enough how calming this was for my skin. I have rosacea and, with irritation comes the dry patches, warm cheeks, and a magenta hue that can be seen from outer space. This is so cooling and hydrating, and I don't need a lot to cover my face. This is one of the few rich night creams that do not break me out or aggravate my skin. You can definitely feel the difference in texture after a week or two. Only con is the high price point, but I guess that's what you get for high-quality ingredients.
Date published: 2018-01-13
Rated 5 out of 5 by from Love it! This is my first time trying out this brand and I’m obsessed! My skin especially in certain areas can get very dry. I’ve tried many different creams and nothing has compared. The texture is amazing and leaves my skin feeling nourished and hydrated! It absorbed into my skin quickly so i didn’t have to wait around to finish up my skin regimen. This product has also helped my skin so much with my occasional breakouts. I have been dealing with these for so long and i have had the best results using this product. I recommend using this daily! Thank you so much Influenster for allowing me to test this product for free. I am now hooked and will continue using!
Date published: 2017-12-02
Rated 5 out of 5 by from Perfect for my dry sensitive skin! As a person that has dry sometimes combination and very sensitive skin it is tough for me to find a moisturizer that is more then just a "basic moisturizer" . The Triple Liquid Restore 2:4:2 has fabulous anti-aging benefits while providing my skin with the rich, creamy (but still not greasy) moisture it needs, especially during the winter months. It leaves my skin feeling hydrated and glowing and allows for a perfect base for my makeup. Sometimes at night I will also out on an extra rich and thick layer to sleep in for added moisture. What I also love about this product is it works so beautifully with other anti-aging serums and products that I use as well.
Date published: 2017-12-01
Rated 3 out of 5 by from Triple Lipid Restore I received a free sample of this product to try from Influenster. I liked the thickness of the cream because even though you could tell it was thick, it never felt heavy or greasy. It has a nice matte finish to it as well, which is one of the pluses as one thing I hate about face creams is having my face feel oily afterwards. However, I'm not sure if the quality made my face feel much more moisturized than using other brands. For the price point, I expected it to blow me out of the water with results, but since the results are similar to other lower priced creams, I don't see myself purchasing it in the future.
Date published: 2018-01-24
Rated 5 out of 5 by from Awesome product!! I received this product for free from Influenster to test and review. I used this cream after I had applied the SkinCeuticals Hyaluronic Acid Intensifier first and I was amazed even after the first application. I have combination/sensitive skin and I am picky as to what I apply to my skin in an effort to avoid any adverse reactions to products. I did not have any reactions to this product and my skin felt so smooth after I applied this to my skin. The best way I can describe it is my face felt like silk afterwards! I live in Arizona where the climate does a number to your skin and I feel that this skin care product will work really well to my restore my skin.
Date published: 2018-01-10
Rated 4 out of 5 by from Made my skin look supple with a youthful glow I received a sample of this product in the mail for testing and before I reviewed their site, I decided to give it a try for a few days to see if I came to a co clusion myself. And yes I did. The formula of this is sooo creamy and moisturizing. Y skin felt silky smooth after the use of this product. Unfortunately the sample was very tiny and I was only able to use it for 2 weeks, twice a day before I ran out. I don’t think 2 weeks is enough time to see significant changes but I did notice every morning (after using this at night) my skin felt very refresh and supple. I had this youthful glow to my skin that made me go a week without foundation to work.
Date published: 2017-12-15
Rated 5 out of 5 by from From scaly to dewy skin I discovered this moisturizer and have been using it daily for 10 months (I have run out and am here to order more). I have AWFUL skin to start with: it is sensitive, I get bouts of cystic acne (I am 27), it's dry, and it looks transparent and discolored. The final straw was last winter when my cheeks got so dry that it became scaly and inflamed. I heard of this moisturizer via a makeup artist and decided to invest in it. BEST choice I've made. The scaliness and redness disappeared and my skin tone evened out to a more uniform color and appeared more plump. Best part is it doesn't irritate my acne in any way. Can't live without this product!
Date published: 2020-01-06
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