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Triple Lipid Restore 2:4:2 Anti-aging cream

Triple Lipid Restore 2:4:2 is rated 4.7 out of 5 by 493.
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A patented anti-aging cream to refill cellular lipids and nourish dry skin. U.S. Patent No. 10,137,073.

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Product Details

Triple Lipid Restore 2:4:2 is an anti-aging cream that contains the optimal and patented lipid ratio of 2% pure ceramides 1 and 3, 4% natural cholesterol, and 2% fatty acids, which is proven to nourish skin and correct signs of aging. This unique lipid correction cream contains the first 2:4:2 cholesterol-dominant ratio to help restore skin's external barrier and support natural self-repair, while potently nourishing aging skin for improvement in the visible appearance of skin smoothness, laxity, pores, and overall radiance.

  • Restores essential skin lipids: ceramides, natural cholesterol, and fatty acids
  • Improves the look of skin fullness, texture, and pore appearance
  • Improves the appearance of skin evenness and overall radiance
  • Unique lipid stabilization system in a lightweight and fast-absorbing texture
  • Shortens the adjustment period to retinoids up to 1 week while reducing dryness (see Science & Proof below)
  • Paraben-, and dye-free
  • Ideal for aging, normal, and dry skin types

Learn more about the science behind Triple Lipid Restore 2:4:2

How To Use

Once or twice daily, apply a small amount between fingertips, warm and melt the cream in circular motions. Apply twice daily to on face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.

  • Visible Results

  • before


    In an 8-week study, Triple Lipid Restore 2:4:2 significantly improved the appearance of key visible signs of accelerated aging:1

    • 66% improvement in smoothness
    • 35% improvement in laxity
    • 20% improvement in evenness
    • 26% improvement in radiance
    • 44% improvement in pore appearance

    In a lipidomic study, use of this cream resulted in a 57% increase in ceramides, 50% increase in cholesterol, and 12% increase in fatty acids in the form of triglycerides.2

    See Protocol

    1Protocol: Average results shown. A dermatologist-controlled 8-week clinical study on 55 subjects with twice daily application of Triple Lipid Restore 2:4:2. Subjects also used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30. Inclusion Criteria: Females ages 55-75 with moderate fi ne lines/wrinkles, uneven skin tone, skin dullness, skin roughness, lack of skin tone clarity, and lack of skin firmness.

    2Protocol: Average results shown. Lipidomics analysis (N=28 females aged 55-75). Statistically significant increase in lipids determined by spectrometric analysis of tape strips collected at baseline and after 8 weeks of twice daily application of Triple Lipid Restore 2:4:2..

  • Science & Proof

  • Science

    Aging skin is increasingly susceptible to lipid depletion: the loss of natural compounds in skin’s surface, present in the predominant form of ceramides, natural cholesterol, and fatty acids. This lipid loss occurs with age and compromises skin’s natural protective barrier, resulting in visible signs of accelerated aging, as skin loses its ability to effectively self-repair. As a result, visible signs of aging may appear more pronounced, in the form of skin roughness, uncomfortable tightness, dullness, and loss of facial fullness.

    Triple Lipid Restore 2:4:2 is the first anti-aging cream to directly address age-related lipid loss with a 2:4:2 cholesterol-dominant ratio, this formulation contains maximized concentration of pure lipids easily utilized by skin.

    Retinoids are known as one of the best anti-aging skin care treatments, but the adjustment period can cause redness, peeling, and flaky skin. Triple Lipid Restore 2:4:2 is now shown to shorten the adjustment period to retinoids up to 1 week while reducing dryness.*

    See Protocol

    *Protocol: 4-week study, on 17 female subjects, ages 38 to 64, who were retinoid averse (self-reported). Subjects applied topical 0.025% tretinoin to their entire face every other evening, or every evening, depending on tolerability. Triple Lipid Restore 2:4:2 and a comparative competitor product were applied to the face twice a day after retinoid application in a split-face, randomized manner.

Key Ingredients

  • 2% Pure Ceramides 1 & 3
  • 4% Natural Cholesterol
  • 2% Fatty Acids
  • Essential oil blend

Part of a larger family of ceramides, and proven to synergistically increase hydration and optimal barrier function

Learn more about Pure Ceramides 1 & 3

See all ingredients

aqua/water/eau, dimethicone, hydrogenated polyisobutene, glycerin, cholesterol, c12-15 alkyl benzoate, ceramide 3, helianthus annuus seed oil unsaponifiables/sunflower seed oil unsaponifiables, bis-peg-18 methyl ether dimethyl silane, sodium polyacrylate, peg-10 dimethicone, nylon-12, lauryl peg-9 polydimethylsiloxyethyl dimethicone, dimethicone/peg-10/15 crosspolymer, phenoxyethanol, disteardimonium hectorite, hydroxyethylpiperazine ethane sulfonic acid, ammonium polyacryloyldimethyl taurate, chlorphenesin, caprylyl glycol, peg/ppg-18/18 dimethicone, propylene carbonate, disodium edta, acrylonitrile/methyl methacrylate/vinylidene chloride copolymer, adenosine, dipropylene glycol, lavandula angustifolia oil/lavender oil, rosmarinus officinalis leaf oil/rosemary leaf oil, t-butyl alcohol, mentha piperita oil/peppermint oil, sodium citrate, linalool, isobutane, ceramide eop, bht, tocopherol, limonene, d182888/1

Physician Insight

Physician image

I think Triple Lipid Restore 2:4:2 is the best corrective cream on the market. I recommend it to all of my patients after surgery to help with the natural dryness that occurs post-op. They love it!

Dr. Michael E. Kelly – Miami Plastic Surgery

Learn about Dr. Michael E. Kelly

Complete Your Regimen


Rated 5 out of 5 by from Great product! I am 42 years old and I have been taking care of my skin since I was 25. I have been using Skinceuticals for the last 6 years and I am extremely happy with their products. I only have fine lines on the outer corner of my eyes that shows when I smile and on my forehead that shows when I lift my eyebrows. Although there is no miracle product that will permanently erase those fine lines, this product definitely helps nourish my skin, making my skin look healthier and most importantly preventing those fines lines from becoming deep wrinkles. I use this product twice a day , it has a thick consistency , but it absorbs quickly. All my skin care products are from skinceuticals, they work really good together and I trust the science behind it.
Date published: 2020-02-24
Rated 5 out of 5 by from I love it I bought this item due to the love of Skinceuticals. I really liked the texture and weight of this moisturizer doesn't feel greasy, a little goes a long way and I will continue to use!
Date published: 2020-02-15
Rated 5 out of 5 by from Love everything about it! I am not a person who is impressed with “hype” and unfounded claims about a product and never write reviews because I am usually disappointed with most products. However, I thought I would splurge and give myself a gift and purchased this because my skin has become dry and wrinkly looking as I am an aging woman. I have used this cream everyday for about one month without any other skin care treatment on my face except my daily makeup and foundation. I can honestly say I have seen a decrease in fine lines and wrinkles especially under my eyes as it is also a wonderful eye cream. I love it’s scent which is fresh and clean and I look forward to putting it on my face everyday. It is not greasy and I use a lot because I just love it. My skin looks smoother and firmer and my pores are smaller which was a nice surprise. I do have some old acne scars on my face which it has not helped but I know it was not meant to. I will definitely be purchasing again!
Date published: 2020-02-10
Rated 5 out of 5 by from BEST PRODUCT FOR DRY SKIN This product was recommended to me by my esthetician when I was on Accutane. If you don’t know, accutane can make your skin severely dry and flaky to the point where no moisturizer was doing the do job. I would have chunks of skin falling off during work and then my skin would get red and irritated because I’d be trying to scrape it off to make it look better. This product along with the phyto corrective gel & masque worked wonders. It helped me tremendously while on accutane and afterwards. I continued to use this product years later. After one use on a dry patch, your skin will be glowing and moisturized like you’ve never seen before. I’m an esthetician and I use numerous product lines but Skin Ceuticals will always be my favorite.
Date published: 2020-01-31
Rated 5 out of 5 by from Great product I needed some more moisturizer and was t really impress .. I use the c-serum brightener and been very happy so after reading reviews I decided to try the lipid restore .. 2.5 weeks user and will continue w my skin regime .. highly recommend .. skin is silky , Dewey :) perfect .. 47 yrs young
Date published: 2020-01-19
Rated 5 out of 5 by from Best night cream ever! I received a sample of this cream and almost ended up giving it to my mom as after going over the ingredients, I thought it'd be more suited for her mature skin. However, I've heard good things about SkinCeuticals and decided to give it a try myself. I'm so glad I did! This cream was my introduction to the brand. I woke up and just kept looking at myself in a mirror because my skin looked so good. In fact, I thought how much younger I looked. A lot of creams leave my skin greasy in the morning, but not this one. My skin looked plump, it was soft, my pores seemed smaller and my number 11s were not as profound. I have combination skin and this cream did not make it greasy at all. Even when I apply it, my skin looks more matte. There was no irritation, no breakouts and it has a very pleasant herbal lavender scent which is in no way strong at all. So, those who are sensitive to smells, rest assure. I would even describe the scent as soothing and calming. Perhaps due to lavender. I then spent quite sometime educating myself about the brand and the products. Although I'm in my mid 30s, I didn't know that there were medical grade skincare and regular beauty stores skincare. Ever since trying SkinCeuticals, I stopped using whatever I've accumulated at skincare/makeup retailers at Malls and other places. With SkinCeuticals I noticed immediate results. After a few more uses, I realized that I could not live without this night cream. So, I bought a night cream and a serum. Fast forward a month later, most of my skincare now consists of SkinCeuticals. Why!?! Because I see results. My skin hasn't looked this good since I was in my 20s. I would rather have two products that work than a graveyard of cremes that don't. My. mom's birthday is coming up, and I will be getting her some SkinCeuticals products as well because they are simply amazing!
Date published: 2020-01-18
Rated 5 out of 5 by from From scaly to dewy skin I discovered this moisturizer and have been using it daily for 10 months (I have run out and am here to order more). I have AWFUL skin to start with: it is sensitive, I get bouts of cystic acne (I am 27), it's dry, and it looks transparent and discolored. The final straw was last winter when my cheeks got so dry that it became scaly and inflamed. I heard of this moisturizer via a makeup artist and decided to invest in it. BEST choice I've made. The scaliness and redness disappeared and my skin tone evened out to a more uniform color and appeared more plump. Best part is it doesn't irritate my acne in any way. Can't live without this product!
Date published: 2020-01-06
Rated 5 out of 5 by from Dewy skin again This, along with the Serum 10 AOX+, has made an incredible difference in my skin. My dry skin with fine wrinkles becomes smooth and dewy with a little bounce. I have very sensitive skin, and I have had no problems with either product. I first tried the Emollience cream and may try it again during the summer, but it was not enough for winter dry skin.
Date published: 2020-01-01
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